Gopalakrishna Harish, Kleiner David E, Kanakry Jennifer A, Ghany Marc G
Department of Liver Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Department of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Case Reports Hepatol. 2025 Aug 13;2025:8411674. doi: 10.1155/crhe/8411674. eCollection 2025.
One of the major complications following hematopoietic cell transplantation (HCT) is the occurrence of graft-versus-host disease (GVHD). The liver is a target organ in both acute and chronic GVHD. Histologically, there are two distinct forms of hepatic involvement by GVHD, namely cholestatic (classical) and hepatic. Autoimmune-like hepatitis has been reported as a late complication of HCT with some considering it to be a variant of hepatic GVHD. However, there are no reports of hepatic form of GVHD and autoimmune-like hepatitis in the same patient post-HCT. Herein, we report a patient who initially developed hepatic GVHD followed by autoimmune-like hepatitis.
造血细胞移植（HCT）后的主要并发症之一是移植物抗宿主病（GVHD）的发生。肝脏是急性和慢性GVHD的靶器官。组织学上，GVHD导致肝脏受累有两种不同形式，即胆汁淤积性（经典型）和肝型。自身免疫性肝炎已被报道为HCT的晚期并发症，一些人认为它是肝GVHD的一种变体。然而，尚无HCT后同一患者出现肝型GVHD和自身免疫性肝炎的报道。在此，我们报告一名患者，其最初发生肝GVHD，随后出现自身免疫性肝炎。
