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沃顿胶间充质基质细胞衍生的细胞外囊泡在体外3D培养系统的炎症应激下减轻椎间盘退变

Wharton's Jelly Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System.

作者信息

Tilotta Veronica, Vadalà Gianluca, Di Giacomo Giuseppina, Ambrosio Luca, Cicione Claudia, Russo Fabrizio, Darinskas Adas, Papalia Rocco, Denaro Vincenzo

机构信息

Laboratory for Regenerative Orthopaedics, Operative Research Unit of Orthopaedic and Trauma Surgery Fondazione Policlinico Universitario Campus Bio-Medico Rome Italy.

Research Unit of Orthopaedic and Trauma Surgery, Departmental Faculty of Medicine and Surgery Università Campus Bio-Medico di Roma Rome Italy.

出版信息

JOR Spine. 2025 Aug 20;8(3):e70106. doi: 10.1002/jsp2.70106. eCollection 2025 Sep.

DOI:10.1002/jsp2.70106
PMID:40842947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12366443/
Abstract

This study explores the therapeutic potential of extracellular vesicles (EVs) derived from Wharton's Jelly mesenchymal stem cells in an in vitro 3D model of intervertebral disc degeneration under inflammatory stress. The treatment with WJ-MSC-EVs enhanced nucleus pulposus cell proliferation, viability, and extracellular matrix synthesis while reducing oxidative stress and catabolic gene expression. These results support the promise of WJ-MSC-EVs as a novel, cell-free strategy for disc regeneration in inflammatory conditions.

摘要

本研究在炎症应激下的体外椎间盘退变三维模型中，探索了源自华通氏胶间充质干细胞的细胞外囊泡（EVs）的治疗潜力。用WJ-MSC-EVs进行治疗可增强髓核细胞增殖、活力和细胞外基质合成，同时减少氧化应激和分解代谢基因表达。这些结果支持了WJ-MSC-EVs作为炎症条件下椎间盘再生的一种新型无细胞策略的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/19033e314972/JSP2-8-e70106-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/cd2ab458e6d0/JSP2-8-e70106-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/8aead359df48/JSP2-8-e70106-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/08ac09f747ad/JSP2-8-e70106-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/6afc3b6d5632/JSP2-8-e70106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/39032aad296e/JSP2-8-e70106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/19033e314972/JSP2-8-e70106-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/cd2ab458e6d0/JSP2-8-e70106-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/8aead359df48/JSP2-8-e70106-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/08ac09f747ad/JSP2-8-e70106-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/6afc3b6d5632/JSP2-8-e70106-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/39032aad296e/JSP2-8-e70106-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28c1/12366443/19033e314972/JSP2-8-e70106-g003.jpg

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本文引用的文献

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Stem Cell Res Ther. 2025 May 1;16(1):221. doi: 10.1186/s13287-025-04299-1.
2
Explorative Study of Modulatory Effects of Notochordal Cell-Derived Extracellular Vesicles on the IL-1β-Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants.脊索细胞衍生的细胞外囊泡对白细胞介素-1β诱导的髓核细胞团块和外植体分解代谢级联反应调节作用的探索性研究
JOR Spine. 2025 Jan 29;8(1):e70043. doi: 10.1002/jsp2.70043. eCollection 2025 Mar.
3
Innovating intervertebral disc degeneration therapy: Harnessing the power of extracellular vesicles.
创新椎间盘退变治疗方法：利用细胞外囊泡的力量
J Orthop Translat. 2025 Jan 7;50:44-55. doi: 10.1016/j.jot.2024.09.014. eCollection 2025 Jan.
4
The proteomic landscape of extracellular vesicles derived from human intervertebral disc cells.源自人椎间盘细胞的细胞外囊泡的蛋白质组学概况。
JOR Spine. 2024 Nov 5;7(4):e70007. doi: 10.1002/jsp2.70007. eCollection 2024 Dec.
5
Getting to the Core: Exploring the Embryonic Development from Notochord to Nucleus Pulposus.深入核心：探索从脊索到髓核的胚胎发育过程。
J Dev Biol. 2024 Jul 3;12(3):18. doi: 10.3390/jdb12030018.
6
A comprehensive review of cell transplantation and platelet-rich plasma therapy for the treatment of disc degeneration-related back and neck pain: A systematic evidence-based analysis.细胞移植和富血小板血浆疗法治疗椎间盘退变相关颈肩腰腿痛的综合综述：基于证据的系统分析
JOR Spine. 2024 Jun 24;7(2):e1348. doi: 10.1002/jsp2.1348. eCollection 2024 Jun.
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Why clinical trials in disc regeneration strive to achieve completion: Insights from publication status and funding sources.椎间盘再生临床试验为何力求完成：来自发表状态和资金来源的见解
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JOR Spine. 2023 Oct 6;7(1):e1274. doi: 10.1002/jsp2.1274. eCollection 2024 Mar.