Hosseini Moghadam Mohammadreza, Omer Hadiya, Dilello Anastasia, Campbell-Enns Lia, Pineda Paula, Neufeld Derek, Ertulova Sofia, Ingram Stephen, Ho Ernest, Rogalsky Tim, Malagon Juan Nicolas
Birmingham City University, Birmingham, England, United Kingdom.
Grant Park High School, Winnipeg, Manitoba, Canada.
MicroPubl Biol. 2025 Aug 6;2025. doi: 10.17912/micropub.biology.001727. eCollection 2025.
Epithelial tissues, the primary origin of most cancers, undergo complex changes in organization and size. Understanding epithelial mechanisms is crucial for elucidating how their disruption leads to cancer, despite the stochastic nature of their dynamics. This study investigates complex spatial and temporal patterns of apical cell area (ACA) oscillations during sex comb rotation in the male forelegs, using . We discovered that, although ACA oscillations appear irregular, the degree of size variation is consistent and predictable. These findings suggest such irregular oscillations may contribute to fine-tuning mechanisms and play a role in maintaining epithelial homeostasis.
上皮组织是大多数癌症的主要起源，其在组织结构和大小上会经历复杂的变化。尽管上皮组织动态变化具有随机性，但了解上皮组织机制对于阐明其破坏如何导致癌症至关重要。本研究利用……调查了雄性前腿性梳旋转过程中顶端细胞面积（ACA）振荡的复杂时空模式。我们发现，尽管ACA振荡看似不规则，但大小变化程度是一致且可预测的。这些发现表明，这种不规则振荡可能有助于微调机制，并在上皮组织稳态维持中发挥作用。
