How Do Small Adjustments in Apical Surface Area Impact Tissue-Wide Homeostasis?

Epithelial tissues, the primary origin of most cancers, undergo complex changes in organization and size. Understanding epithelial mechanisms is crucial for elucidating how their disruption leads to cancer, despite the stochastic nature of their dynamics. This study investigates complex spatial and temporal patterns of apical cell area (ACA) oscillations during sex comb rotation in the male forelegs, using . We discovered that, although ACA oscillations appear irregular, the degree of size variation is consistent and predictable. These findings suggest such irregular oscillations may contribute to fine-tuning mechanisms and play a role in maintaining epithelial homeostasis.