Ginsburg W W, Cohen M D, Hall S B, Vollertsen R S, Hunder G G
Arthritis Rheum. 1985 Dec;28(12):1362-6. doi: 10.1002/art.1780281208.
Nineteen of 520 patients with biopsy-proven giant cell arteritis were found to have persistent seronegative, symmetric polyarthritis with a mean joint count of 20 (swollen plus tender). In 9 patients in the onset of polyarthritis occurred prior to the diagnosis of giant cell arteritis, 3 had simultaneous onset, and 7 developed polyarthritis within 3 years after the onset of giant cell arteritis. Ten of the 19 patients demonstrated radiographic features of joint space narrowing and/or erosions. In 1 patient in a synovial biopsy was performed, revealing marked multinucleated giant cell infiltration. A persistent seronegative polyarthritis, although uncommon in giant cell arteritis, may be its presenting symptom. Other symptoms of giant cell arteritis should be sought in patients who exhibit this feature, especially in those whose arthritis begins at age 50 or older.
在520例经活检证实为巨细胞动脉炎的患者中，有19例出现持续的血清阴性、对称性多关节炎，平均关节计数为20个（肿胀关节数加压痛关节数）。在9例患者中，多关节炎在巨细胞动脉炎诊断之前就已出现，3例同时发病，7例在巨细胞动脉炎发病后3年内出现多关节炎。19例患者中有10例表现出关节间隙变窄和/或侵蚀的影像学特征。对1例患者进行了滑膜活检，显示有明显的多核巨细胞浸润。持续的血清阴性多关节炎虽然在巨细胞动脉炎中不常见，但可能是其首发症状。对于出现这种特征的患者，尤其是那些关节炎始于50岁及以上的患者，应寻找巨细胞动脉炎的其他症状。
