Cakmak Suheda, Turkmen Ismail, Kulali Fatma, Saglam Necdet, Unnu Selda Cakin, Basat Sema Ucak
Department of Internal Medicine, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkiye.
Department of Orthopaedics and Traumatology, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkiye.
North Clin Istanb. 2025 Jun 12;12(3):327-336. doi: 10.14744/nci.2024.74340. eCollection 2025.
There is limited knowledge regarding the clinical, biochemical, and functional characteristics of patients with osteosarcopenia. The present study aims to explore the presence of osteosarcopenia in patients aged 65 years and over who have a history of falls and hip fractures.
Seventy-six participants (77.6% women) aged 65 years and over (mean age 81±6.75 years) were admitted to the orthopedic clinic of our hospital due to hip fracture. The diagnosis of osteopenia/osteoporosis was established based on the bone mineral density measurement using dual-energy X-ray absorptiometry. The SARC-F scale was used to screen patients for sarcopenia. The muscle mass was determined by the appendicular lean mass (ALM). The muscle strength was evaluated by the handgrip strength. SPSS for Windows 25.0 (IBM Statistical Package for Social Sciences) software package was used in the statistical analysis of the study data.
A total of 76 patients were evaluated, including 59 (77.6%) females and 17 (22.4%) males. The mean age of the patients was 81±6.75 years. The prevalence of osteosarcopenia in the entire study group was 36.8%. The prevalence rate was higher in males (59%) than in females (30.5%) (p<0.05). The ALM and the handgrip strength were lower in patients with osteosarcopenia (p<0.05). The mean body weight, total fat mass, fat mass index, and upper arm circumference were the lowest in the group of patients with osteosarcopenia (p<0.05).
The present study found that the prevalence of osteosarcopenia was higher in patients with hip fracture. There is a limited number of studies in literature directly evaluating the relationship between osteosarcopenia and hip fracture. The presence of osteosarcopenia is often overlooked when the bone fracture is the prevailing clinical condition. Osteosarcopenia is frequently the accompanying diagnosis in patients with hip fracture.
关于骨质疏松性肌少症患者的临床、生化和功能特征，人们了解有限。本研究旨在探讨65岁及以上有跌倒和髋部骨折病史的患者中骨质疏松性肌少症的存在情况。
76名65岁及以上（平均年龄81±6.75岁）的参与者（77.6%为女性）因髋部骨折入住我院骨科门诊。根据双能X线吸收法测量的骨密度确定骨质减少/骨质疏松的诊断。使用SARC-F量表对患者进行肌少症筛查。肌肉质量通过四肢瘦体重（ALM）来确定。肌肉力量通过握力进行评估。研究数据的统计分析使用了Windows 25.0版的SPSS（IBM社会科学统计软件包）软件包。
共评估了76例患者，其中女性59例（77.6%），男性17例（22.4%）。患者的平均年龄为81±6.75岁。整个研究组中骨质疏松性肌少症的患病率为36.8%。男性患病率（59%）高于女性（30.5%）（p<0.05）。骨质疏松性肌少症患者的ALM和握力较低（p<0.05）。骨质疏松性肌少症患者组的平均体重、总脂肪量、脂肪量指数和上臂围最小（p<0.05）。
本研究发现髋部骨折患者中骨质疏松性肌少症的患病率较高。文献中直接评估骨质疏松性肌少症与髋部骨折之间关系的研究数量有限。当骨折是主要临床情况时，骨质疏松性肌少症的存在常常被忽视。骨质疏松性肌少症经常是髋部骨折患者的伴随诊断。
