Ungureanu Daniel, Mitrea Patricia-Ștefania, Iluț Silvina, Taloș Aurora, Crișan Cătălina-Angela
Department Pharmacy I, Discipline of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
"Prof. Dr. Ion Chiricuță" Oncology Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania.
Reports (MDPI). 2025 Aug 2;8(3):134. doi: 10.3390/reports8030134.
: Neuroleptic malignant syndrome (NMS) is a life-threatening condition usually caused by the exposure to antipsychotics. This case report presents a catatonia syndrome that may have developed in the context of a moderate NMS. : An 18-year-old male patient presented with a treatment-resistant catatonia syndrome that debuted 2 weeks prior to the presentation (creatin kinase levels = 4908 U/L, maximum temperature = 38.9°C, white blood count = 13.20 × 10/L, Bush-Francis Catatonia Rating Scale = 30 points). Possible organic causes of catatonia were ruled out, according to the negative results obtained. The patient's condition improved under benzodiazepine treatment and he was later discharged. After discharge, the catatonia was attributed to a possible NMS with moderate severity. The diagnosis was supported by NMS Diagnosis Criteria Score = 85 points and the presence of Levenson's triad. : This case highlights the concomitant manifestation of both catatonia and NMS in the same patient and the difficulty of establishing a correct diagnosis involving both entities.
: 抗精神病药恶性综合征(NMS)是一种通常由接触抗精神病药物引起的危及生命的病症。本病例报告介绍了一例可能在中度NMS背景下发生的紧张症综合征。: 一名18岁男性患者出现了难治性紧张症综合征,在就诊前2周首次出现(肌酸激酶水平 = 4908 U/L,最高体温 = 38.9°C,白细胞计数 = 13.20×10/L,布什-弗朗西斯紧张症评定量表 = 30分)。根据获得的阴性结果,排除了紧张症可能的器质性病因。患者在苯二氮䓬类药物治疗下病情好转,随后出院。出院后,紧张症归因于可能的中度严重NMS。NMS诊断标准评分为85分以及存在莱文森三联征支持了该诊断。: 本病例突出了同一患者中紧张症和NMS的伴随表现以及对涉及这两种病症的正确诊断的建立困难。