Montazeri Katayoon, Chaibakhsh Samira, Fekrazad Reza
Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Radiation Sciences Research Center (RSRC), Aja University of Medical Sciences, Tehran, Islamic Republic of Iran.
Lasers Med Sci. 2025 Aug 22;40(1):341. doi: 10.1007/s10103-025-04601-w.
Transcranial photobiomodulation (tPBM) uses the light of lasers or light-emitting diodes to modulate and improve brain function. In this study, the use of tPBM for improving cerebral circulation and modulating brain neural oscillations has been systematically reviewed to determine the useful parameters of tPBM and the grade of its practical recommendation. The PROSPERO code "CRD42023393544". "Google scholar", "Pub Med", "Scopus" and "science direct" online databases were searched based on Preferred Reporting Items for Systematic Reviews and meta-analyses (PRISMA) guidelines. Search keywords were "low level laser therapy AND cerebral circulation" OR "photobiomodulation therapy AND cerebral circulation" OR "low level laser therapy AND brain neural oscillation" OR "photobiomodulation therapy AND brain neural oscillations". Reviews, preprints, non-transcranial PBM, patents, unpublished articles, non-English articles, case reports and non-related articles were excluded. Forty-five studies published from January 2009 to May 2024, including 18 animal studies and 27 human studies, were included. 808 (810) nanometer (nm) and 1064 nm wavelengths, power density of 250 mW/cm and energy density in the range of 60-120 J/cm were the most used tPBM parameters. The human studies included 19 randomized clinical trials (RCTs), and the Cochrane Risk of Bias Tool for Randomized Trials (RoB2) was used to assess quality of the RCTs to determine the level of evidence and grade of practical recommendations. According to the grade practice recommendations, tPBM is strongly recommended for modulating brain neural oscillations and improving cognitive processes. In addition, tPBM is recommended for increasing cerebral blood flow, metabolism and oxygenation.
经颅光生物调节疗法（tPBM）利用激光或发光二极管发出的光来调节和改善脑功能。在本研究中，对tPBM改善脑循环和调节脑神经元振荡的应用进行了系统综述，以确定tPBM的有效参数及其实际推荐等级。PROSPERO注册号为“CRD42023393544”。根据系统评价和Meta分析的首选报告项目（PRISMA）指南，检索了“谷歌学术”“PubMed”“Scopus”和“科学Direct”在线数据库。检索关键词为“低强度激光疗法与脑循环”或“光生物调节疗法与脑循环”或“低强度激光疗法与脑神经元振荡”或“光生物调节疗法与脑神经元振荡”。排除综述、预印本、非经颅PBM、专利、未发表文章、非英文文章、病例报告及无关文章。纳入了2009年1月至2024年5月发表的45项研究，其中包括18项动物研究和27项人体研究。808（810）纳米（nm）和1064 nm波长、250 mW/cm的功率密度以及60 - 120 J/cm范围内的能量密度是最常用的tPBM参数。人体研究包括19项随机临床试验（RCT），采用随机试验的Cochrane偏倚风险工具（RoB2）评估RCT的质量，以确定证据水平和实际推荐等级。根据分级实践推荐，强烈推荐tPBM用于调节脑神经元振荡和改善认知过程。此外，推荐tPBM用于增加脑血流量、代谢和氧合。
