Cheng Xunshu, Memon Muhammad Azhar, Ali Waseem, Ma Yonggang
Sichuan University of Arts and Science, 635000, Dashon, People's Republic of China.
College of Veterinary Medicine, Yangzhsou University, Yangzhou, 225009, Jiangsu, People's Republic of China.
J Mol Histol. 2025 Aug 22;56(5):272. doi: 10.1007/s10735-025-10499-z.
As a common chronic disease, endometriosis (EMs) affects nearly 10% of women of childbearing age, may cause other complications such as infertility, and has a tendency to develop malignant tumors. Ferroptosis is a newly discovered apoptotic process characterized by intracellular free iron excess, which mediates Fenton reaction and eventually leads to lipid peroxidation in the cell membrane leading to cell death. The abnormal changes of intracellular iron concentration may lead to the accumulation of reactive oxygen species (ROS) and the imbalance of redox homeostasis, thus leading to the occurrence of iron death. At present, the pathogenesis and effect of iron death on EMs are not completely clear, and the study of its physiological and pathological mechanism is very important for its diagnosis and treatment. This article reviews the research progress of the occurrence and development of EMs in order to provide new ideas for the pathogenesis, diagnosis and treatment of EMs.
作为一种常见的慢性病，子宫内膜异位症（EMs）影响着近10%的育龄女性，可能引发不孕等其他并发症，且有发展为恶性肿瘤的倾向。铁死亡是一种新发现的凋亡过程，其特征是细胞内游离铁过量，介导芬顿反应，最终导致细胞膜脂质过氧化，从而导致细胞死亡。细胞内铁浓度的异常变化可能导致活性氧（ROS）积累和氧化还原稳态失衡，进而引发铁死亡。目前，铁死亡在EMs中的发病机制和作用尚不完全清楚，对其生理和病理机制的研究对其诊断和治疗非常重要。本文综述了EMs发生发展的研究进展，以期为EMs的发病机制、诊断和治疗提供新思路。
