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经颅聚焦超声作用于伏隔核可逆转大鼠中芬太尼诱导的条件性位置偏爱。

Transcranial focused ultrasound to nucleus accumbens reverses fentanyl-induced conditioned place preference in rats.

作者信息

Yoo Seung-Schik, Ewell Madeline S, Smith Evan C, Yu Isabel L, Kim Hyun-Chul, Desai Rajeev I

机构信息

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

Behavioral Biology Program, Integrative Neurochemistry Laboratory, McLean Hospital, Belmont, Massachusetts, United States of America.

出版信息

PLoS One. 2025 Aug 22;20(8):e0329748. doi: 10.1371/journal.pone.0329748. eCollection 2025.

DOI:10.1371/journal.pone.0329748
PMID:40845058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12373176/
Abstract

Fentanyl-related opioid use disorder (OUD) continues to be a substantial public health concern. Current pharmacological treatments, using methadone and buprenorphine, can cause adverse side effects, and patients often relapse, necessitating alternative treatment strategies. Transcranial focused ultrasound (tFUS), a noninvasive neuromodulation technique with deep brain penetrability and high spatial selectivity, is emerging as a potential intervention for treatment of OUD. To evaluate utility of tFUS in modulating the function of reward circuitry, we applied functionally suppressive tFUS to the nucleus accumbens (nAcc) of male rats to determine if it attenuated fentanyl-induced conditioned place preference (CPP). Fentanyl CPP scores were significantly attenuated following tFUS administration to the nAcc, suggesting tFUS application weakens the rewarding effects of fentanyl in rats. Physiological, behavioral, and neuropathological endpoints were unaffected by tFUS, confirming that other factors did not contribute to the observed effects. Taken together, these results support the use of tFUS as a potential treatment strategy of OUD by non-invasively modulating activity in key reward-related brain regions implicated in OUD.

摘要

芬太尼相关的阿片类物质使用障碍（OUD）仍然是一个重大的公共卫生问题。目前使用美沙酮和丁丙诺啡的药物治疗可能会引起不良副作用，而且患者经常复发，因此需要替代治疗策略。经颅聚焦超声（tFUS）是一种具有深部脑穿透性和高空间选择性的非侵入性神经调节技术，正逐渐成为治疗OUD的一种潜在干预手段。为了评估tFUS在调节奖赏回路功能方面的效用，我们对雄性大鼠的伏隔核（nAcc）施加功能性抑制性tFUS，以确定其是否能减弱芬太尼诱导的条件性位置偏爱（CPP）。向nAcc施加tFUS后，芬太尼CPP评分显著降低，这表明tFUS的应用减弱了芬太尼对大鼠的奖赏作用。生理、行为和神经病理学终点均未受tFUS影响，这证实了其他因素并未导致观察到的效果。综上所述，这些结果支持将tFUS作为一种潜在的治疗策略，通过非侵入性调节与OUD相关的关键奖赏相关脑区的活动来治疗OUD。

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本文引用的文献

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超声玻片：用于超高通量分析细胞类型特异性神经调制的体外平台，采用超低强度超声刺激。
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