大鼠胎儿的血浆钙调控。III. 母体血浆钙变化对胎儿血浆钙水平的影响。

Plasma calcium control in the rat fetus. III. Influence of alterations in maternal plasma calcium on fetal plasma calcium level.

作者信息

Chalon S, Garel J M

出版信息

Biol Neonate. 1985;48(6):329-35. doi: 10.1159/000242189.

Abstract

Acute maternal alterations in plasma calcium were used as an indirect mean to study the placental transfer of calcium in thyroparathyroidectomized (TPTX) pregnant rats. Calcium infusions to normal or TPTX females showed in both cases a saturation mechanism reflected on fetal plasma calcium. With TPTX mothers saturation curves of the fetal plasma calcium were similar whether fetuses were decapitated (deprived of brain, hypophysis, and thyroparathyroid complex) or intact. Increments in fetal plasma calcium were 4-fold higher in TPTX mothers (approximately 2.5 mg/dl), and 2-fold higher in thyroidectomized (TX) mothers (approximately 0.5 mg/dl). From the whole results, it appeared that increments in fetal plasma calcium secondary to maternal calcium infusion were probably related to the basal plasma calcium in the fetus, and not to the hormonal deficiency of the mother.

摘要

急性母体血浆钙变化被用作一种间接手段，以研究甲状旁腺切除（TPTX）的怀孕大鼠中钙的胎盘转运。对正常或TPTX雌性大鼠输注钙，在两种情况下均显示出一种饱和机制，这反映在胎儿血浆钙上。对于TPTX母亲，无论胎儿是断头（去除脑、垂体和甲状旁腺复合体）还是完整，胎儿血浆钙的饱和曲线都是相似的。TPTX母亲的胎儿血浆钙增量高4倍（约2.5mg/dl），甲状腺切除（TX）母亲的胎儿血浆钙增量高2倍（约0.5mg/dl）。从整体结果来看，似乎母体输注钙继发的胎儿血浆钙增量可能与胎儿的基础血浆钙有关，而与母亲的激素缺乏无关。