Chalon S, Garel J M
C R Seances Acad Sci III. 1982 Feb 1;294(5):257-60.
The relative fetal autonomy for plasma calcium in regard to the maternal plasma value led us to investigate a possible effect of maternal hormones on the placental transfer of calcium. For this purpose we have used pregnant Rats deprived of endogenous calcitonin (CT) by thyroidectomy (TX) or thyroparathyroidectomy (TPTX). Increases in fetal plasma calcium of 0.87 mg/dl for TX mothers, 2.46 mg/dl for TPTX mothers, and 0.54 mg/dl for normal mothers occurred at the end of a 1 hr. maternal calcium infusion 3.6 mg/100 g body weight) at 21.5 days of gestation. The absence of CT in TX and TPTX mothers and the already known reduced levels of placental Calcium-binding protein (CaBP) in TPTX Rats might explain these results. Maternal CT seems to have an inhibitory effect on the placental transfer of calcium, whereas placental CaBP might play a more important role as a "buffer".
胎儿血浆钙相对于母体血浆值具有相对自主性，这促使我们研究母体激素对钙胎盘转运的可能影响。为此，我们使用了通过甲状腺切除术（TX）或甲状腺甲状旁腺切除术（TPTX）去除内源性降钙素（CT）的怀孕大鼠。在妊娠21.5天时，对母体进行1小时的钙输注（3.6毫克/100克体重）后，TX组母体的胎儿血浆钙增加了0.87毫克/分升，TPTX组母体增加了2.46毫克/分升，正常母体增加了0.54毫克/分升。TX和TPTX组母体中CT的缺失以及TPTX大鼠中已知的胎盘钙结合蛋白（CaBP）水平降低可能解释了这些结果。母体CT似乎对钙的胎盘转运具有抑制作用，而胎盘CaBP可能作为“缓冲剂”发挥更重要的作用。
