Wechman R, Brown M, Hilton F
Biol Reprod. 1985 Nov;33(4):803-7. doi: 10.1095/biolreprod33.4.803.
Female mouse fetuses that develop in utero implanted between two male fetuses (2M females) are shown as adults to have significantly elevated (P less than 0.01) levels of beta-glucuronidase activity in their preputial glands compared to that of OM females, females that had not been contiguous to males in utero, and 1M females, females contiguous in utero to only one male (mean +/- SEM, 2M females = 23,9 +/- 2.1, 1M females = 13.3 +/- 5.2, and OM females = 7.8 +/- 2.5 Modified Sigma Units/mg frozen weight). It is hypothesized that the increased enzymatic activity in the preputial glands of 2M females could be important in releasing steroid metabolites from voided urine. These metabolites could then act as pheromones and thus explain some of the described differences in sexual behavior correlated with intrauterine position.
在子宫内发育时处于两个雄性胎儿之间的雌性小鼠胎儿（2M雌性）成年后，其包皮腺中β-葡萄糖醛酸酶活性水平与未在子宫内与雄性相邻的OM雌性、1M雌性（子宫内仅与一个雄性相邻的雌性）相比显著升高（P小于0.01）（平均值±标准误，2M雌性 = 23.9±2.1，1M雌性 = 13.3±5.2，OM雌性 = 7.8±2.5改良西格玛单位/毫克冻重）。据推测，2M雌性包皮腺中酶活性的增加可能对从排出的尿液中释放类固醇代谢物很重要。这些代谢物然后可以作为信息素，从而解释一些与子宫内位置相关的性行为差异。
