Suppr超能文献

药物遗传学正在被种族化吗?对现代生物医学中种族观念重新铭刻的调查。

Is pharmacogenetics being racialized? An investigation into the reinscription of racial beliefs in modern biomedicine.

作者信息

Steimle Lena, Schües Christina

机构信息

Faculty of Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.

Institute for the History of Medicine and Science Studies, University of Lübeck, Königstraße 42, 23552, Lübeck, Germany.

出版信息

Theor Med Bioeth. 2025 Oct;46(5):349-375. doi: 10.1007/s11017-025-09723-4. Epub 2025 Aug 22.

Abstract

Racial classifications have a complex and troubled past in the social and scientific history of humankind. They are the result of racism and have been used to devalue and degrade non-White people. Although the concept of race has acquired a social component and the genetic similarity of people based on race has been proven, the category is increasingly used in pharmacogenetic studies to create biased study populations under the guise of personalized medicine. The heart failure drug BiDil, which was only approved for Black people in 2005, gained particular notoriety. Its race-specific approval reignited the debate about the assumption that there are genetic differences between people of different races and led to a further biopolitical instrumentalization of the term 'race'. Despite the expiry of the race-specific patent, race-specific labeling continues to take place in research. In this paper, these racializations of pharmacogenetics are examined, explaining how they arise and how they are kept alive. Finally, this paper argues for better moderation of race in pharmacogenetic studies.

摘要

种族分类在人类社会和科学史上有着复杂且麻烦的过去。它们是种族主义的产物,一直被用来贬低和诋毁非白人。尽管种族概念已经有了社会层面的含义,而且基于种族的人群基因相似性也已得到证实,但在药物遗传学研究中,这个类别越来越多地被用于以个性化医疗为幌子创建有偏差的研究群体。2005年才被批准仅用于黑人的心力衰竭药物BiDil尤其声名狼藉。其针对特定种族的批准重新引发了关于不同种族人群之间存在基因差异这一假设的辩论,并导致了“种族”一词在生物政治层面的进一步工具化。尽管针对特定种族的专利已经过期,但在研究中针对特定种族的标注仍在继续。本文审视了药物遗传学中的这些种族化现象,解释了它们是如何产生以及如何持续存在的。最后,本文主张在药物遗传学研究中更好地调节对种族的使用。

相似文献

1
Is pharmacogenetics being racialized? An investigation into the reinscription of racial beliefs in modern biomedicine.
Theor Med Bioeth. 2025 Oct;46(5):349-375. doi: 10.1007/s11017-025-09723-4. Epub 2025 Aug 22.
3
The Black Book of Psychotropic Dosing and Monitoring.
Psychopharmacol Bull. 2024 Jul 8;54(3):8-59.
5
A Shadow of Doubt: Is There Implicit Bias Among Orthopaedic Surgery Faculty and Residents Regarding Race and Gender?
Clin Orthop Relat Res. 2024 Jul 1;482(7):1145-1155. doi: 10.1097/CORR.0000000000002933. Epub 2024 Jan 12.
7
A Spectrum of Understanding: A Qualitative Exploration of Autistic Adults' Understandings and Perceptions of Friendship(s).
Autism Adulthood. 2024 Dec 2;6(4):438-450. doi: 10.1089/aut.2023.0051. eCollection 2024 Dec.

本文引用的文献

1
New Consensus Report Recommends against the Use of Race in Genetic Research.
Clin Chem. 2023 Aug 2;69(8):941-942. doi: 10.1093/clinchem/hvad076.
2
Use of race, ethnicity, and ancestry data in health research.
PLOS Glob Public Health. 2022 Sep 15;2(9):e0001060. doi: 10.1371/journal.pgph.0001060. eCollection 2022.
4
Imperfect Improvement: Estimating Kidney Filtration without a Race Coefficient.
Clin Chem. 2022 Mar 31;68(4):487-488. doi: 10.1093/clinchem/hvac018.
5
Cardiologists' Perspectives on BiDil and the Use of Race in Drug Prescribing.
J Racial Ethn Health Disparities. 2022 Dec;9(6):2146-2156. doi: 10.1007/s40615-021-01153-x. Epub 2022 Feb 3.
6
Health inequities and the inappropriate use of race in nephrology.
Nat Rev Nephrol. 2022 Feb;18(2):84-94. doi: 10.1038/s41581-021-00501-8. Epub 2021 Nov 8.
7
Race and Biomedicine Beyond the Lab: 21st Century Mobilisations of Genetics-Introduction to the Special Issue.
Biosocieties. 2021;16(4):433-446. doi: 10.1057/s41292-021-00261-5. Epub 2021 Oct 27.
8
Striving for Diversity in Research Studies.
N Engl J Med. 2021 Oct 7;385(15):1429-1430. doi: 10.1056/NEJMe2114651. Epub 2021 Sep 13.
9
The perspectives of health professionals and patients on racism in healthcare: A qualitative systematic review.
PLoS One. 2021 Aug 31;16(8):e0255936. doi: 10.1371/journal.pone.0255936. eCollection 2021.
10
Updated Guidance on the Reporting of Race and Ethnicity in Medical and Science Journals.
JAMA. 2021 Aug 17;326(7):621-627. doi: 10.1001/jama.2021.13304.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验