Steimle Lena, Schües Christina
Faculty of Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Institute for the History of Medicine and Science Studies, University of Lübeck, Königstraße 42, 23552, Lübeck, Germany.
Theor Med Bioeth. 2025 Oct;46(5):349-375. doi: 10.1007/s11017-025-09723-4. Epub 2025 Aug 22.
Racial classifications have a complex and troubled past in the social and scientific history of humankind. They are the result of racism and have been used to devalue and degrade non-White people. Although the concept of race has acquired a social component and the genetic similarity of people based on race has been proven, the category is increasingly used in pharmacogenetic studies to create biased study populations under the guise of personalized medicine. The heart failure drug BiDil, which was only approved for Black people in 2005, gained particular notoriety. Its race-specific approval reignited the debate about the assumption that there are genetic differences between people of different races and led to a further biopolitical instrumentalization of the term 'race'. Despite the expiry of the race-specific patent, race-specific labeling continues to take place in research. In this paper, these racializations of pharmacogenetics are examined, explaining how they arise and how they are kept alive. Finally, this paper argues for better moderation of race in pharmacogenetic studies.
种族分类在人类社会和科学史上有着复杂且麻烦的过去。它们是种族主义的产物,一直被用来贬低和诋毁非白人。尽管种族概念已经有了社会层面的含义,而且基于种族的人群基因相似性也已得到证实,但在药物遗传学研究中,这个类别越来越多地被用于以个性化医疗为幌子创建有偏差的研究群体。2005年才被批准仅用于黑人的心力衰竭药物BiDil尤其声名狼藉。其针对特定种族的批准重新引发了关于不同种族人群之间存在基因差异这一假设的辩论,并导致了“种族”一词在生物政治层面的进一步工具化。尽管针对特定种族的专利已经过期,但在研究中针对特定种族的标注仍在继续。本文审视了药物遗传学中的这些种族化现象,解释了它们是如何产生以及如何持续存在的。最后,本文主张在药物遗传学研究中更好地调节对种族的使用。