Patel Krushangi, Lee Percy, Weng Julius, Melstrom Laleh, Raoof Mustafa, Lewis Aaron, Chung Vincent
City of Hope Department of Medical Oncology & Therapeutics Research, City of Hope Comprehensive Cancer Center Long Beach, Long Beach, CA, USA.
Department of Radiation Oncology, City of Hope Orange County Lennar Foundation Cancer Center, Irvine, CA, USA.
Cancer Treat Res. 2025;129:221-266. doi: 10.1007/978-3-031-97242-3_11.
Immunotherapeutic approaches have created effective therapy with a manageable toxicity profile as a new treatment approach in a wide variety of cancers, often leading to longer responses and control of disease. In pancreatic cancer, responses to immunotherapy have been difficult to capture. Many obstacles have been identified in the limited efficacy of immunotherapy in pancreatic cancers. The hostile tumor microenvironment plays a large role in therapeutic development of immune-based therapies in pancreatic cancer. The approach to addressing many of these challenges will require a team-based approach to optimize both our understanding of the disease, its microenvironment, and how each component behaves in the development and growth of pancreatic cancer as well as the mechanisms used to best create therapies and combinations of treatment that will have long-standing efficacy for pancreatic cancer patients.
免疫治疗方法作为一种新的治疗方法，在多种癌症中创造了具有可控毒性特征的有效治疗，通常能带来更长时间的反应和疾病控制。在胰腺癌中，免疫治疗的反应一直难以捉摸。在胰腺癌免疫治疗的有限疗效中已发现许多障碍。恶劣的肿瘤微环境在胰腺癌基于免疫疗法的治疗发展中起很大作用。应对这些挑战中的许多挑战需要一种基于团队的方法，以优化我们对疾病、其微环境以及胰腺癌发展和生长过程中每个组成部分的行为的理解，以及用于最佳创建对胰腺癌患者具有长期疗效的治疗方法和联合治疗的机制。
