Luo Wentao, Chen Yifei, Shen Danjing, Zhang Yiyang, Zhang Wentao, Xu Tianyuan, Chen Haotian, Cao Xiangqian, Yan Yilin, Yang Bin, Li Wei, Shen Bing
Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Urologic Cancer Institute, School of Medicine, Tongji University, Shanghai, China.
Ann Med. 2025 Dec;57(1):2549525. doi: 10.1080/07853890.2025.2549525. Epub 2025 Aug 22.
Bladder cancer and emotional stress are both common physiologic problems, with few published studies and a lack of studies with large samples discussing their association. The aim of this study was to investigate the association between bladder cancer and emotional stress.
We used data from the U.S. National Health and Nutrition Examination Survey (NHANES) database for the period 2005 to 2020 and the Bladder Cancer Database from Shanghai Tenth People's Hospital of Tongji University. The above two databases were used for two independent cross-sectional studies, respectively. We adopted the method of multivariate logistic regression to analyze the relationship between the occurrence of bladder cancer and depression, as well as the relationship between the recurrence of bladder cancer and emotional stress.
Based on the NHANES database, a total of 23,801 participants were enrolled in our study, including 100 participants diagnosed with bladder cancer and 23,701 participants not diagnosed with bladder cancer. After adjustment for covariates, there was a significant positive association between bladder cancer and mild depression (OR: 2.43, 95% CI: 1.41, 4.00). There was a significant positive association between recurrence of bladder cancer and general depression (OR: 2.16, 95% CI: 1.20, 3.88) among 303 bladder cancer patients in the Chinese database.
This study reveals a strong association between bladder cancer and emotional stress, with patients with bladder cancer having a significant risk of depression and elevated emotional stress potentially associated with bladder cancer recurrence.
膀胱癌和情绪应激都是常见的生理问题，但相关发表的研究较少，且缺乏大样本研究探讨它们之间的关联。本研究旨在调查膀胱癌与情绪应激之间的关联。
我们使用了美国国家健康与营养检查调查（NHANES）数据库2005年至2020年期间的数据以及同济大学附属上海市第十人民医院的膀胱癌数据库。上述两个数据库分别用于两项独立的横断面研究。我们采用多因素逻辑回归方法分析膀胱癌发生与抑郁之间的关系，以及膀胱癌复发与情绪应激之间的关系。
基于NHANES数据库，共有23,801名参与者纳入我们的研究，其中包括100名被诊断为膀胱癌的参与者和23,701名未被诊断为膀胱癌的参与者。在对协变量进行调整后，膀胱癌与轻度抑郁之间存在显著的正相关（OR：2.43，95%CI：1.41，4.00）。在中国数据库的303例膀胱癌患者中，膀胱癌复发与总体抑郁之间存在显著的正相关（OR：2.16，95%CI：1.20，3.88）。
本研究揭示了膀胱癌与情绪应激之间存在密切关联，膀胱癌患者有显著的抑郁风险，情绪应激升高可能与膀胱癌复发有关。
