Huang Si, Liu Bowen, Peng Fei, Wang Yong, Han Shuai, Tu Yingfeng
Laboratory of Research of New Chinese Medicine, Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Adv Mater. 2025 Aug 23:e08865. doi: 10.1002/adma.202508865.
Micro/nano technology offers advantages such as higher adsorption efficiency and lower toxicity in drug delivery; however, passive systems that depend on passive distribution face challenges in penetrating physiological barriers. In contrast, micro/nanomotors (MNMs) with self-propulsion capabilities powered by energy sources like chemical reactions and physical fields show great potential for enhancing barrier penetration. Their active motion facilitates stronger tissue interaction and improves efficiency in crossing strict physiological barriers designed to protect vital areas but hinder drug delivery under abnormal conditions. This manuscript provides a critical introduction to MNMs-based drug delivery systems, reviews recent advances in overcoming physiological barriers and targeted drug delivery, and summarizes the challenges and future research priorities, aiming to offer guidelines for further development. With continuous innovation, MNMs represent a promising strategy to enhance targeted drug delivery efficiency across physiological barriers.
微纳技术在药物递送方面具有诸如更高的吸附效率和更低的毒性等优势；然而，依赖被动分布的被动系统在穿透生理屏障方面面临挑战。相比之下，由化学反应和物理场等能源驱动具有自推进能力的微纳马达（MNMs）在增强屏障穿透方面显示出巨大潜力。它们的主动运动促进了更强的组织相互作用，并提高了穿越旨在保护重要区域但在异常情况下阻碍药物递送的严格生理屏障的效率。本文对基于微纳马达的药物递送系统进行了批判性介绍，综述了在克服生理屏障和靶向药物递送方面的最新进展，并总结了挑战和未来研究重点，旨在为进一步发展提供指导。随着不断创新，微纳马达是提高跨生理屏障靶向药物递送效率的一种有前景的策略。
