Terman G W, Liebeskind J C
Brain Res. 1985 Dec 30;361(1-2):405-7. doi: 10.1016/0006-8993(85)91313-7.
We have previously reported that non-opioid stress analgesia and two forms of opioid stress analgesia can be differentially produced in rats by varying the severity or temporal pattern of inescapable footshock. In this study, we investigated the role of muscarinic cholinergic mechanisms in mediating these 3 forms of stress analgesia. Whereas the muscarinic anticholinergic drug, scopolamine, had no effect on either non-opioid stress analgesia or opioid stress analgesia from 1 min of continuous 2.5-mA footshock, it significantly attenuated opioid analgesia from 20 min of intermittent footshock at this same intensity. The data are discussed in reference to other similarities and differences between these two forms of opioid stress analgesia.
我们之前曾报道，通过改变不可逃避的足部电击的强度或时间模式，可在大鼠中差异地产生非阿片类应激镇痛和两种形式的阿片类应激镇痛。在本研究中，我们研究了毒蕈碱胆碱能机制在介导这三种应激镇痛形式中的作用。毒蕈碱抗胆碱能药物东莨菪碱对持续2.5毫安足部电击1分钟所产生的非阿片类应激镇痛或阿片类应激镇痛均无影响，但它显著减弱了在相同强度下间歇性足部电击20分钟所产生的阿片类镇痛作用。我们结合这两种阿片类应激镇痛形式之间的其他异同对数据进行了讨论。
