Russell R D, Stripling J S
Brain Res. 1985 Dec 30;361(1-2):61-9. doi: 10.1016/0006-8993(85)91275-2.
The potential evoked in the pyriform cortex by single-pulse stimulation of the olfactory bulb was examined before and after single and repeated elicitation of an epileptiform afterdischarge produced by stimulation of the olfactory bulb. A single afterdischarge (AD) produced a rapid (i.e. within 5 min) increase in the amplitude of an early surface-negative wave and duration of a later surface-positive wave. These effects persisted at least 48-72 h. Repeated elicitation of ADs resulted in kindling. A large increase in the amplitude of a later surface-negative wave (approximately 25 ms latency) occurred during kindling. This wave remained significantly elevated for at least 72 h after the last AD. Long-term potentiation of the early surface-negative wave was produced by kindling or two focal ADs. A short-term effect which was consistently observed following a focal or generalized AD was a prolongation of a late surface-positive wave. These effects are discussed in relation to long-term potentiation, postseizure inhibition, and kindling development.
在由嗅球刺激诱发的癫痫样后放电单次和重复引发之前及之后，检测了通过嗅球单脉冲刺激在梨状皮质中诱发的电位。单次后放电（AD）使早期表面负波的幅度迅速（即5分钟内）增加，以及后期表面正波的持续时间增加。这些效应至少持续48 - 72小时。重复引发AD导致点燃。在点燃过程中，后期表面负波（潜伏期约25毫秒）的幅度大幅增加。在最后一次AD后，该波至少72小时内仍显著升高。点燃或两次局灶性AD产生了早期表面负波的长期增强。在局灶性或全身性AD后始终观察到的短期效应是后期表面正波的延长。讨论了这些效应与长期增强、发作后抑制和点燃发展的关系。
