神经活动对突触小泡分布的影响。
The effect of nerve activity on the distribution of synaptic vesicles.
作者信息
Maler L, Mathieson W B
出版信息
Cell Mol Neurobiol. 1985 Dec;5(4):373-87. doi: 10.1007/BF00755402.
Abstract
Certain gymnotid fish (apteronotids) continuously emit a high-frequency electric-organ discharge and thus continuously drive their electroreceptor afferents at high rates. Electroreceptor afferents terminate in one lamina of the electrosensory lateral line lobe (ELL) and can be readily sampled. Normally these terminals have many small vesicles clustered adjacent to the presynaptic membrane. When afferent activity is blocked for 24 hr by an injection of tetrodotoxin (TTX) into the electroreceptor nerve, the density of vesicles adjacent to the synaptic membrane declines; the volume of the remaining vesicles increases. If the nerve of a TTX-treated fish is stimulated proximal to the injection site, these changes can be reversed. These results imply that the migration of vesicles toward the presynaptic membrane is influenced by the level of activity in the nerve.
摘要
某些裸背电鳗科鱼类（无背鳍电鳗）持续发出高频电器官放电，从而以高速率持续驱动其电感受器传入神经。电感受器传入神经在电感觉侧线叶（ELL）的一层终止，并且可以很容易地进行采样。正常情况下，这些终末在突触前膜附近有许多聚集的小囊泡。当通过向电感受器神经注射河豚毒素（TTX）使传入活动被阻断24小时时，突触膜附近的囊泡密度下降；剩余囊泡的体积增加。如果在注射部位近端刺激经TTX处理的鱼的神经，这些变化可以逆转。这些结果表明囊泡向突触前膜的迁移受神经活动水平的影响。
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