Waelkens J
Cephalalgia. 1985 Dec;5(4):223-8. doi: 10.1046/j.1468-2982.1985.0504223.x.
The characteristics of warning symptoms preceding the migraine headache attack in 49 patients with complete migraine are described. These symptoms are divided into non-evolutive and evolutive warning symptoms, based on specific characteristics of each. Non-evolutive symptoms precede the attack by 8 to 48 h in 88% of our patients and have a constant and modest intensity. Evolutive warning symptoms appear within a few minutes up to 6 h before the attack. These symptoms become more and more pronounced towards the onset of the headache. There was no striking similarity between symptoms during the attack and the warning symptoms. In a number of patients with complete migraine, migraine attacks can be prevented by taking domperidone, a peripheral dopamine antagonist, at the time of the non-evolutive warning symptoms. These data suggest that the mechanism leading to a migraine attack can be operative 8-48 h before the headache begins and is possibly dopaminergically mediated.
描述了49例完全性偏头痛患者偏头痛发作前先兆症状的特征。根据每种症状的具体特点，这些症状分为非进展性和进展性先兆症状。在我们的患者中，88%的非进展性症状在发作前8至48小时出现，且强度恒定且适中。进展性先兆症状在发作前几分钟至6小时内出现。这些症状在头痛发作时变得越来越明显。发作期间的症状与先兆症状之间没有明显的相似性。在一些完全性偏头痛患者中，在非进展性先兆症状出现时服用外周多巴胺拮抗剂多潘立酮可预防偏头痛发作。这些数据表明，导致偏头痛发作的机制可能在头痛开始前8 - 48小时起作用，并且可能由多巴胺能介导。
