Jung Ahrang, Crowder Victoria, Chan Ya-Ning, Klemm Dawn, Tan Kelly R, Poor Elissa Herman, Okanlawon Bankole Ayomide, Anderson Danielle Steele, Coppola Susan, Pergolotti Mackenzi, Schwartz Todd A, Richardson Daniel R, Leak Bryant Ashley
Ahrang Jung.
Victoria Crowder.
Oncol Nurs Forum. 2025 Aug 18;52(5):382-392. doi: 10.1188/25.ONF.382-392.
To explore perspectives of older adults (aged 60 years or older) with acute myeloid leukemia (AML) on their physical function and mobility, assessed at three time points during treatment with a hypomethylating agent and venetoclax (HMA + VEN).
PARTICIPANTS & SETTING: Participants were older adults with AML (N = 17) receiving HMA + VEN at a comprehensive cancer center. Most were male and aged 64-89 years (median age = 75 years).
This study used a longitudinal qualitative approach with semistructured interviews at cycles 1, 2, and 7 of chemotherapy. Interviews were audio recorded, transcribed, coded, and analyzed using thematic analysis.
Four themes were identified: reduced mobility and limited options for physical activities (cycle 1), periodic changes in mobility and energy level (cycle 2), acceptance and adaptation to changed mobility (cycle 7), and strategies to stay active.
Substantial challenges with physical function and mobility exist for older adults undergoing treatment for AML. Oncology nurses should anticipate patient needs, provide appropriate care, and make referrals to address physical and functional needs before and during HMA + VEN treatment.
探讨老年急性髓系白血病（AML）患者（年龄60岁及以上）在接受去甲基化药物与维奈克拉联合治疗（HMA + VEN）期间三个时间点对其身体功能和活动能力的看法。
参与者为在一家综合癌症中心接受HMA + VEN治疗的老年AML患者（N = 17）。大多数为男性，年龄在64 - 89岁之间（中位年龄 = 75岁）。
本研究采用纵向定性研究方法，在化疗的第1、2和7周期进行半结构化访谈。访谈进行录音、转录、编码，并采用主题分析法进行分析。
确定了四个主题：活动能力下降和体育活动选择受限（第1周期）、活动能力和能量水平的周期性变化（第2周期）、对活动能力变化的接受和适应（第7周期）以及保持活跃的策略。
接受AML治疗的老年人在身体功能和活动能力方面存在重大挑战。肿瘤护理人员应预测患者需求，提供适当护理，并在HMA + VEN治疗前和治疗期间进行转诊，以满足患者的身体和功能需求。
