Chronic wounds refer to wounds that fail to achieve complete structural repair within the expected time frame despite standardized systemic treatment, which are characterized by high incidence, complex mechanisms, prolonged clinical course, and difficulty in treatment. Topical growth factor drugs or biological agents, which regulate cell proliferation, migration, and differentiation, thereby effectively promoting the wound healing process, are widely used in the repair of various acute and chronic wounds. However, there is still some controversy over the application of topical growth factors in the clinical practice of treating various chronic wounds. Chinese Burn Association and Editorial Committee of jointly initiated and organized a multidisciplinary expert group. Based on current evidence-based medical evidence, clinical practice, and authoritative guidelines from other disciplines, this clinical expert consensus was developed for further standardization of the application of topical growth factors in the clinical treatment of chronic wounds.