Department of Burns and Plastic Surgery, General Technology Gemstone Flower Healthcare Jilin City Hospital of Chemical Industry Jilin, Jilin, China.
Medicine (Baltimore). 2024 Nov 1;103(44):e39672. doi: 10.1097/MD.0000000000039672.
This study aimed to evaluate the efficacy of combining autologous platelet-rich plasma (PRP) with negative pressure wound therapy (NPWT) for the repair of pressure ulcers. We included 90 patients with pressure ulcers from General Technology Gemstone Flower Healthcare Jilin City Hospital of Chemical Industry between January 2021 and December 2023. Patients were randomly assigned to either a control group or an observation group, with 45 patients in each. The control group received NPWT alone, while the observation group received a combination of PRP and NPWT. Outcomes were compared between the groups, including clinical efficacy, wound recovery time (infection control time, wound healing time, hospital stay), levels of inflammatory markers (C-reactive protein, erythrocyte sedimentation rate, white blood cell count), pain scores (numerical rating scale), Pressure Ulcer Scale for Healing scores, and incidence of complications. The observation group demonstrated a total effective rate of 95.56% (43/45), significantly higher than the control group's 80.00% (35/45) (P < .05). Additionally, the observation group had significantly shorter infection control times, wound healing times, and hospital stays (P < .05). Two weeks post-surgery, the observation group had significantly lower levels of C-reactive protein, erythrocyte sedimentation rate, and white blood cell count, as well as reduced numerical rating scale and Pressure Ulcer Scale for Healing scores (P < .05). The incidence of complications was 6.67% (3/45) in the observation group compared to 33.33% (15/45) in the control group, with a significant difference (P < .05). Combining autologous PRP with NPWT significantly improves clinical outcomes, reduces inflammatory responses, decreases pain, accelerates wound healing, and lowers complication rates in patients with pressure ulcers.
本研究旨在评估富血小板血浆（PRP）联合负压伤口疗法（NPWT）治疗压疮的疗效。我们纳入了 2021 年 1 月至 2023 年 12 月期间吉林石化总医院宝石花医院收治的 90 例压疮患者。将患者随机分为对照组和观察组，每组 45 例。对照组单独接受 NPWT 治疗，观察组则接受 PRP 联合 NPWT 治疗。比较两组患者的临床疗效、创面恢复时间（感染控制时间、创面愈合时间、住院时间）、炎症标志物（C 反应蛋白、红细胞沉降率、白细胞计数）水平、疼痛评分（数字评分量表）、压疮愈合评分及并发症发生率。观察组总有效率为 95.56%（43/45），明显高于对照组的 80.00%（35/45）（P<0.05）。观察组的感染控制时间、创面愈合时间和住院时间明显更短（P<0.05）。术后 2 周，观察组的 C 反应蛋白、红细胞沉降率和白细胞计数水平明显更低，疼痛评分和压疮愈合评分明显更低（P<0.05）。观察组并发症发生率为 6.67%（3/45），对照组为 33.33%（15/45），差异有统计学意义（P<0.05）。自体 PRP 联合 NPWT 可显著改善压疮患者的临床疗效，减轻炎症反应，缓解疼痛，加速创面愈合，降低并发症发生率。
