Nicolae Camelia, Păun Nicolae, Munteanu Mădălina Andreea, Florescu Cristina, Uscoiu Gabriela, Munteanu Alice Elena, Bolohan Mihaela Paula, Nanea Ioan Tiberiu
Department of Cardiology and Internal Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;
Rom J Morphol Embryol. 2025 Apr-Jun;66(2):385-390. doi: 10.47162/RJME.66.2.12.
Cardiac remodeling is a relevant and unfavorable evolution of myocardial infarction, which is associated with an increased risk of progression to overt heart failure (HF). It is currently acknowledged as a fundamental therapeutic objective that clinicians must address from the acute event to the comprehensive clinical follow-up.
The aim of the study was to assess the importance of left ventricular hypertrophy (LVH) in acute myocardial infarction (AMI) extension.
PATIENTS, MATERIALS AND METHODS: Inclusion criteria: anterior V1-V4 ST-segment elevation myocardial infarction (STEMI) and left ventricular ejection fraction (LVEF) >50%.
other STEMI locations, heart disorders, systemic diseases. Patients underwent pharmacological or percutaneous revascularization. Echocardiography was performed until day 3 of AMI and after 14 days. To measure the length of the expansion segment (LES), an original mathematical formula was obtained using the parasternal short-axis view at the papillary muscle level, myocardial mass (MM), and interventricular septum thickness (IST). Statistical studies have used the Student's t-test, the linear regression equations and the Pearson's correlation coefficient.
172 AMI patients were analyzed and divided into two groups. Patients with LVH showed a strong reverse Pearson's correlation coefficient between LES and IST. For group II, a significant strongly reverse correlation for the LES and IST.
Pre-existing LVH in AMI is associated with the limitation of the expansion. In the group without LVH, a 1 cm increase in LES corresponds to a 0.0622 cm decrease in IST.
心脏重塑是心肌梗死的一种相关且不利的演变过程，与进展为明显心力衰竭（HF）的风险增加相关。目前，这被公认为临床医生必须从急性事件到全面临床随访都要关注的一个基本治疗目标。
本研究的目的是评估左心室肥厚（LVH）在急性心肌梗死（AMI）扩展中的重要性。
患者、材料与方法：纳入标准：前壁V1 - V4 ST段抬高型心肌梗死（STEMI）且左心室射血分数（LVEF）>50%。
其他STEMI部位、心脏疾病、全身性疾病。患者接受了药物或经皮血管重建治疗。在AMI第3天及14天后进行超声心动图检查。为测量扩张段长度（LES），利用乳头肌水平的胸骨旁短轴视图、心肌质量（MM）和室间隔厚度（IST）获得了一个原始数学公式。统计研究采用了学生t检验、线性回归方程和皮尔逊相关系数。
对172例AMI患者进行了分析并分为两组。LVH患者的LES与IST之间呈现出很强的反向皮尔逊相关系数。对于第二组，LES与IST之间存在显著的强反向相关性。
AMI中预先存在的LVH与扩张受限相关。在无LVH组中，LES每增加1 cm，IST相应减少0.0622 cm。
