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毁形性关节炎:一名61岁无指(趾)炎的银屑病患者的银屑病性疾病的毁灭性表现

Arthritis Mutilans: A Devastating Manifestation of Psoriatic Disease Without Dactylitis in a 61-Year-Old Patient.

作者信息

Altamirano De La Cruz Azalea Guadalupe, Lugo Rincón-Gallardo Francisco Javier, Salazar López Maria Daniela, Ruedas Rodriguez Celtzin Jazbeth, Mendoza Gómez Jennifer Miriam

机构信息

Internal Medicine, Mexican Social Security Institute (IMSS) General Zone Hospital No. 8, Ensenada, MEX.

Internal Medicine, Institute for Social Security and Services for State Workers, Ensenada, MEX.

出版信息

Cureus. 2025 Jul 22;17(7):e88502. doi: 10.7759/cureus.88502. eCollection 2025 Jul.

Abstract

Arthritis mutilans (AM) is the most severe and least common form of psoriatic arthritis (PsA), characterized by digital shortening due to osteolysis and often associated with profound functional disability. We report a case of a 61-year-old male with longstanding plaque psoriasis and poor treatment adherence who developed AM affecting the interphalangeal joints of the left foot, with significant joint deformity and extensive skin involvement (30% body surface area). Imaging revealed severe bone breakdown, leading to the affected phalanges of the foot appearing shortened or telescoped. AM typically presents in patients with distal interphalangeal joint involvement and is often linked to a history of dactylitis. Although rare, it can also appear in other rheumatic conditions, including rheumatoid arthritis and systemic lupus erythematosus. Current challenges include the absence of standardized phenotypic definitions and a limited understanding of clinical predictors. Early identification of at-risk patients is critical to prevent irreversible joint damage and disability.

摘要

毁形性关节炎(AM)是银屑病关节炎(PsA)最严重且最不常见的形式,其特征是由于骨质溶解导致手指缩短,且常伴有严重的功能残疾。我们报告一例61岁男性,患有长期斑块状银屑病且治疗依从性差,发生了累及左脚指间关节的AM,伴有明显的关节畸形和广泛的皮肤受累(体表面积30%)。影像学检查显示严重的骨质破坏,导致足部受累指骨出现缩短或套叠。AM通常出现在远端指间关节受累的患者中,且常与指(趾)炎病史有关。虽然罕见,但它也可出现在其他风湿性疾病中,包括类风湿关节炎和系统性红斑狼疮。当前的挑战包括缺乏标准化的表型定义以及对临床预测因素的了解有限。早期识别高危患者对于预防不可逆的关节损伤和残疾至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/602d/12368913/fc75ddaf5648/cureus-0017-00000088502-i01.jpg

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