系统性红斑狼疮中的关节炎：源自2022年国际GISEA/OEG研讨会
Arthritis in Systemic Lupus Erythematosus: From 2022 International GISEA/OEG Symposium.
作者信息
Ceccarelli Fulvia, Govoni Marcello, Piga Matteo, Cassone Giulia, Cantatore Francesco Paolo, Olivieri Giulio, Cauli Alberto, Favalli Ennio Giulio, Atzeni Fabiola, Gremese Elisa, Iannone Florenzo, Caporali Roberto, Sebastiani Marco, Ferraccioli Gian Franco, Lapadula Giovanni, Conti Fabrizio
机构信息
Lupus Clinic, Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza University of Rome, 00161 Rome, Italy.
Rheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, 44124 Ferrara, Italy.
出版信息
J Clin Med. 2022 Oct 12;11(20):6016. doi: 10.3390/jcm11206016.
Musculoskeletal involvement is one of the most common manifestations of systemic lupus erythematosus (SLE), with a negative impact on both quality of life and overall prognosis. SLE arthritis can be classified into three different subtypes, with different prevalence and characteristic biomarkers and MRI findings. Identifying the pathogenetic mechanisms underlying musculoskeletal manifestations' development is crucial to develop therapeutic strategies to suppress synovial inflammation, prevent erosions and deformities, and improve SLE patients' quality of life. Hence, here we discuss the main pathogenetic mechanisms and therapeutic approaches of musculoskeletal manifestations of SLE from the 2022 International GISEA/OEG Symposium.
肌肉骨骼受累是系统性红斑狼疮（SLE）最常见的表现之一，对生活质量和总体预后均有负面影响。SLE关节炎可分为三种不同亚型，具有不同的患病率、特征性生物标志物和MRI表现。明确肌肉骨骼表现发生发展的致病机制对于制定抑制滑膜炎症、预防侵蚀和畸形以及改善SLE患者生活质量的治疗策略至关重要。因此，在此我们讨论来自2022年国际GISEA/OEG研讨会的SLE肌肉骨骼表现的主要致病机制和治疗方法。
Zotero 插件