Chen Gang, Zhao Xin, Yang Bin, Gu Hongzheng
Department of Implant and Restoration, Zhenjiang Stomatological Hospital, Zhenjiang, China.
Central Laboratory of Zhenjiang Stomatological Hospital, Zhenjiang, China.
Front Microbiol. 2025 Aug 7;16:1639095. doi: 10.3389/fmicb.2025.1639095. eCollection 2025.
Peri-implant disease is a chronic infection-induced inflammation condition affecting tissues around dental implants, categorized into peri-implant mucositis and peri-implantitis. Oral microbial dysbiosis plays an important role in this disease. Currently, researchers face three challenges in establishing the pathogenic link between peri-implant disease and microdysbiosis: (1) elucidating the underlying molecular mechanisms; (2) Clarifying causal links between host and microbiome; and (3) Identifying secondary microbial changes during disease progression. In this review, we systematically classify dysbiosis from a conceptual perspective and outline the immunological associations within each category. We further elaborate on the causes of bacterial dysbiosis and analyze its potential implications for clinical treatment strategies. At the molecular level, understanding the origins, intrinsic and environmental regulatory mechanisms, and downstream effects may be conducive to develop microbiome targeted therapies. This research direction is of great significance for promoting precision medicine in peri-implant disease.
种植体周围疾病是一种由慢性感染引起的炎症性疾病，影响牙种植体周围的组织，分为种植体周围黏膜炎和种植体周围炎。口腔微生物群落失调在这种疾病中起重要作用。目前，研究人员在建立种植体周围疾病与微生物群落失调之间的致病联系上面临三个挑战：（1）阐明潜在的分子机制；（2）明确宿主与微生物组之间的因果关系；（3）确定疾病进展过程中的继发性微生物变化。在本综述中，我们从概念角度对失调进行系统分类，并概述每一类中的免疫关联。我们进一步阐述细菌失调的原因，并分析其对临床治疗策略的潜在影响。在分子水平上，了解其起源、内在和环境调节机制以及下游效应可能有助于开发针对微生物组的疗法。这一研究方向对促进种植体周围疾病的精准医学具有重要意义。
