Biologics in Orthopaedics: Is Platelet-Rich Plasma Ready for Widespread Clinical Use?

Biological therapies such as platelet-rich plasma (PRP), stem cells, and bone marrow aspirate concentrate have gained attention in orthopaedics as potential alternatives to conventional interventions. PRP, in particular, has been extensively studied in spinal disorders, tendinopathies, and cartilage lesions. While encouraging evidence suggests symptomatic improvement and functional recovery in selected patients, limitations such as a lack of standardisation, variability in preparation, and limited long-term outcomes hinder universal adoption. In our clinical experience, patients are increasingly curious about PRP, often asking about its cost, availability, and expected outcomes. Although many report short-term relief, sustained long-term benefits remain inconsistent. This editorial discusses the current evidence, practical challenges, and future direction of PRP in orthopaedic practice.