用于合成二胺化前体配体的2,6-二溴吡啶的选择性单胺化和二胺化
Selective Mono- and Diamination of 2,6-Dibromopyridine for the Synthesis of Diaminated Proligands.
作者信息
Underwood Alexander S, Botrous Mark A, Lobb Nate T, Neal Emmett M, Richter Charlotte A, Sleiman Mathieu A, Frye Adrian B, Roberts Matthew, Padgett Clifford W, Guillet Gary L
机构信息
Department of Chemistry, Furman University, Greenville, South Carolina 29613, United States.
Department of Biochemistry, Chemistry, and Physics, Georgia Southern University-Armstrong Campus, Savannah, Georgia 31419, United States.
出版信息
ACS Omega. 2025 Aug 11;10(32):36321-36327. doi: 10.1021/acsomega.5c04396. eCollection 2025 Aug 19.
Selective mono- or diaminations of 2,6-dibromopyridine were performed using microwave irradiation with water as solvent in 2-2.5 h. The only significant difference between the syntheses was the inclusion of KCO as base and CuI/DMPAO catalyst for the diaminations. The mono- and diaminations had approximately 7 and 2 g isolated yields, respectively. The monoaminated bromopyridines were attached to a TREN scaffolding molecule yielding novel ligands to support extended metal atom chain complexes.
在以水为溶剂的条件下，使用微波辐射在2 - 2.5小时内对2,6 - 二溴吡啶进行了选择性单胺化或二胺化反应。这些合成之间唯一显著的差异在于，二胺化反应中加入了碳酸钾作为碱以及碘化亚铜/二甲基哌嗪酮催化剂。单胺化和二胺化反应的分离产率分别约为7克和2克。单胺化的溴吡啶与三(2 - 氨基乙基)胺支架分子相连，生成了用于支持扩展金属原子链配合物的新型配体。
Zotero 插件