Da Cruz Simone, Mason Kylie, Renwick William, Said Joanne M, Cutts Briony A
Department of Obstetrics, Western Health, St Albans, Australia.
Department of Haematology, Royal Melbourne Hospital, Parkville, Australia.
Obstet Med. 2025 Aug 19:1753495X251356377. doi: 10.1177/1753495X251356377.
Hairy cell leukaemia (HCL) represents less 1% of all lymphoid neoplasms with cases rarely reported in pregnancy. Management of HCL requires multidisciplinary care to optimise maternal and neonatal outcomes.
A literature search of Ovid MEDLINE and EMBASE for 'hairy cell leukaemia' and 'Pregnancy' was undertaken.
Thirteen cases were reviewed including three within our own institutions. Interferon-alpha was the most prominent treatment at varying doses in n = 3 (23%) patients. Other management included antenatal cladribine and rituximab, post-partum cladribine with and without rituximab, laparoscopic splenectomy and termination of pregnancy. 46.1% (n = 6) of patients birthed vaginally. Due to thrombocytopenia, there was a greater proportion of caesarean delivery under general anaesthetic and half of the cases documented bleeding complications.
Diagnosis and management of HCL in pregnancy is difficult. Women can be managed safely and outcome aims should be the same as non-pregnant patients.
毛细胞白血病（HCL）占所有淋巴样肿瘤的比例不到1%，孕期病例鲜有报道。HCL的管理需要多学科护理，以优化母婴结局。
对Ovid MEDLINE和EMBASE进行文献检索，检索词为“毛细胞白血病”和“妊娠”。
共回顾了13例病例，其中3例来自我们自己的机构。α干扰素是最主要的治疗方法，n = 3（23%）例患者使用了不同剂量。其他治疗包括产前使用克拉屈滨和利妥昔单抗、产后使用克拉屈滨（加或不加利妥昔单抗）、腹腔镜脾切除术和终止妊娠。46.1%（n = 6）的患者经阴道分娩。由于血小板减少，剖宫产全麻的比例更高，且有一半的病例记录有出血并发症。
孕期HCL的诊断和管理具有挑战性。女性患者可得到安全管理，治疗目标应与非孕期患者相同。
