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Relationship between effect site concentration of remimazolam at loss of consciousness and time to extubation: a prospective, single-centre, observational study.

作者信息

Shirozu Kazuhiro, Nakamura Yuri, Asada Masako, Takamori Shinnosuke, Ando Taichi, Yamaura Ken

机构信息

Operating rooms, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Department of Anaesthesiology and Critical Care Medicine, Kyushu University Hospital, Fukuoka, Japan.

出版信息

J Clin Monit Comput. 2025 Aug 25. doi: 10.1007/s10877-025-01349-0.

DOI:10.1007/s10877-025-01349-0
PMID:40853426
Abstract
摘要

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Relationship between effect site concentration of remimazolam at loss of consciousness and time to extubation: a prospective, single-centre, observational study.瑞马唑仑效应室浓度与意识消失至拔管时间的关系：一项前瞻性、单中心观察性研究。
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3
The degree of respiratory depression according to the effect-site concentration in remimazolam target-controlled infusion: A randomised controlled trial.瑞马唑仑靶控输注时按效应室浓度预测呼吸抑制的程度：一项随机对照试验。
Eur J Anaesthesiol. 2024 Oct 1;41(10):728-737. doi: 10.1097/EJA.0000000000002045. Epub 2024 Jul 29.
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Alfentanil Enhanced the Sedation of Remimazolam During Anaesthesia Induction in Patients Undergoing Urological Day Surgery: A Randomised Controlled Trial.阿芬太尼增强泌尿外科日间手术患者麻醉诱导期间瑞马唑仑的镇静效果：一项随机对照试验
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本文引用的文献

1
Development and analysis of a remimazolam pharmacokinetics and pharmacodynamics model with proposed dosing and concentrations for anaesthesia and sedation.一种用于麻醉和镇静的瑞马唑仑药代动力学和药效学模型的开发与分析，并提出给药方案和浓度建议。
Br J Anaesth. 2025 Jul;135(1):206-217. doi: 10.1016/j.bja.2025.02.038. Epub 2025 Apr 30.
2
Equilibration rate constant, k, to determine effect-site concentration for the Masui remimazolam population pharmacokinetic model in general anesthesia patients.平衡速率常数 k，用于确定 Masui 咪达唑仑群体药代动力学模型在全麻患者中的效应部位浓度。
J Anesth. 2022 Dec;36(6):757-762. doi: 10.1007/s00540-022-03099-8. Epub 2022 Aug 26.
3
A population pharmacokinetic model of remimazolam for general anesthesia and consideration of remimazolam dose in clinical practice.
瑞马唑仑用于全身麻醉的群体药代动力学模型及临床剂量的考虑。
J Anesth. 2022 Aug;36(4):493-505. doi: 10.1007/s00540-022-03079-y. Epub 2022 Jun 16.
4
Effects of CYP2C19*17 genetic polymorphisms on plasma and saliva concentrations of diazepam in patients with alcohol withdrawal syndrome.CYP2C19*17基因多态性对酒精戒断综合征患者血浆和唾液中地西泮浓度的影响。
Psychiatr Genet. 2022 Apr 1;32(2):67-73. doi: 10.1097/YPG.0000000000000306.
5
Neurological sedative indicators during general anesthesia with remimazolam.瑞马唑仑全身麻醉时的神经镇静指标。
J Anesth. 2022 Apr;36(2):194-200. doi: 10.1007/s00540-021-03030-7. Epub 2022 Jan 9.
6
Population pharmacokinetic/pharmacodynamic modeling for remimazolam in the induction and maintenance of general anesthesia in healthy subjects and in surgical subjects.瑞马唑仑在健康受试者和手术受试者全身麻醉诱导和维持中的群体药代动力学/药效学建模。
J Clin Anesth. 2020 Nov;66:109899. doi: 10.1016/j.jclinane.2020.109899. Epub 2020 Jun 22.
7
Efficacy and safety of remimazolam versus propofol for general anesthesia: a multicenter, single-blind, randomized, parallel-group, phase IIb/III trial.瑞马唑仑与丙泊酚用于全身麻醉的有效性和安全性：一项多中心、单盲、随机、平行分组、Ⅱb/Ⅲ期临床试验。
J Anesth. 2020 Aug;34(4):543-553. doi: 10.1007/s00540-020-02788-6. Epub 2020 May 16.
8
Safety and efficacy of remimazolam in induction and maintenance of general anesthesia in high-risk surgical patients (ASA Class III): results of a multicenter, randomized, double-blind, parallel-group comparative trial.瑞马唑仑用于高危手术患者全麻诱导和维持的安全性和有效性（ASA 分级 III）：一项多中心、随机、双盲、平行组比较试验的结果。
J Anesth. 2020 Aug;34(4):491-501. doi: 10.1007/s00540-020-02776-w. Epub 2020 Apr 17.
9
Time-to-Event Modeling for Remimazolam for the Indication of Induction and Maintenance of General Anesthesia.用于全身麻醉诱导和维持的瑞米唑仑的事件发生时间建模。
J Clin Pharmacol. 2020 Apr;60(4):505-514. doi: 10.1002/jcph.1552. Epub 2020 Jan 27.
10
Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part II. Pharmacodynamics of Electroencephalogram Effects.雷米佐仑（CNS 7056）在健康男性志愿者中连续输注的药代动力学和药效学：第二部分。脑电图效应的药效学。
Anesthesiology. 2020 Apr;132(4):652-666. doi: 10.1097/ALN.0000000000003102.