Rzaeva N A, Abdullaev F I, Ivanova T P, Dobrynin Ia V
Eksp Onkol. 1985;7(6):67-9.
The effect of different inorganic and organic selenium compounds on the nucleic acid synthesis in culture of human carcinoma ovary cells was studied. The rate of synthesis was determined by the incorporation of 3H-thymidine in the DNA and 3H-uridine in the RNA. Selenium compounds in the concentration to 1 mg/ml inhibited the nucleic acid synthesis in human tumour cells. The level of nucleic acid inhibition depends on the concentration of examined compounds. The tetravalent selenium compounds possessed the most pronounced cytotoxic effect.
研究了不同无机和有机硒化合物对人卵巢癌细胞培养物中核酸合成的影响。通过DNA中3H-胸腺嘧啶核苷和RNA中3H-尿嘧啶核苷的掺入来测定合成速率。浓度达1mg/ml的硒化合物抑制人肿瘤细胞中的核酸合成。核酸抑制水平取决于所检测化合物的浓度。四价硒化合物具有最显著的细胞毒性作用。
