小鼠颌下腺中激肽酶活性的性别差异。

Sexual difference in kininase activity in the mouse submandibular gland.

作者信息

Kashimata M, Hiramatsu M, Kumegawa M, Minami N, Minami N

出版信息

Enzyme. 1985;34(1):22-6. doi: 10.1159/000469355.

Abstract

A marked sexual difference in kininase activity was found in the adult mouse submandibular gland. The activity was over 3-fold higher in females than in males between 10 and 12 weeks of age. Castration of male mice increased kininase activity up to the level of females. Testosterone administration to castrated males restored enzyme activity to about the normal level. Moreover, testosterone administration to normal females decreased enzyme activity to about the level of normal male mice, while ovariectomy had no effect. These results suggest that kininase activity in the mouse submandibular gland is suppressively regulated by endogenous androgen.

摘要

在成年小鼠颌下腺中发现了激肽酶活性存在明显的性别差异。在10至12周龄时，雌性小鼠的激肽酶活性比雄性小鼠高3倍以上。对雄性小鼠进行阉割会使激肽酶活性升高至雌性小鼠的水平。给阉割后的雄性小鼠注射睾酮可使酶活性恢复至正常水平。此外，给正常雌性小鼠注射睾酮会使酶活性降低至正常雄性小鼠的水平，而卵巢切除则没有影响。这些结果表明，小鼠颌下腺中的激肽酶活性受到内源性雄激素的抑制性调节。