Wu Jialin, Liu Yutao, Liu Ruiying, Xiao Changyi, Xuan Leyan, Wu Lili, Qian Jiamin, Qin Xudong, Hou Yingying, Xie Maobin, Yu Xiyong, Liu Bin, Tang Guosheng
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P. R. China.
School of Life Sciences, Faculty of Medicine, Tianjin University, Tianjin, China.
Nat Commun. 2025 Aug 25;16(1):7924. doi: 10.1038/s41467-025-63276-7.
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition with rising global incidence and limited treatment options. Current therapies often have poor efficacy and undesirable side effects. Here we present a drug-free strategy that targets bacterial adhesion to manage IBD. We develop porous microgels loaded with mannan oligosaccharides (MOS) that mimic the natural binding sites of intestinal cells. These microgels attract adherent-invasive Escherichia coli (AIEC) by interacting with FimH, a bacterial protein used for attachment, thereby preventing AIEC from colonizing the gut lining. The microgels are fabricated using an all-aqueous two-phase system, enabling biocompatibility and structural control. In a mouse model of IBD, this competitive adsorption approach alleviates intestinal inflammation, reduces harmful Enterobacteriaceae, and enhances gut microbial diversity. This work introduces a non-antibiotic, bioinspired method that intercepts pathogenic bacteria and restores microbial balance, offering a promising therapeutic strategy for IBD.
炎症性肠病（IBD）是一种慢性免疫介导性疾病，全球发病率不断上升，治疗选择有限。目前的治疗方法往往疗效不佳且副作用不理想。在此，我们提出一种针对细菌黏附的无药策略来治疗IBD。我们开发了负载甘露寡糖（MOS）的多孔微凝胶，其模拟肠道细胞的天然结合位点。这些微凝胶通过与用于黏附的细菌蛋白FimH相互作用来吸引黏附侵袭性大肠杆菌（AIEC），从而防止AIEC在肠壁定植。微凝胶使用全水两相系统制备，具有生物相容性并能控制结构。在IBD小鼠模型中，这种竞争性吸附方法可减轻肠道炎症，减少有害肠杆菌科细菌，并增强肠道微生物多样性。这项工作引入了一种非抗生素、受生物启发的方法，该方法可拦截病原菌并恢复微生物平衡，为IBD提供了一种有前景的治疗策略。
