Lièvre M, Morin M H, Lakhal M, Faucon G
Eur J Pharmacol. 1985 Oct 29;117(1):103-7. doi: 10.1016/0014-2999(85)90477-7.
The intracisternal administration of nicergoline (5 micrograms/kg) or clonidine (4 micrograms/kg) in chloralose-anesthetized dogs induced significant decreases in blood pressure and heart rate. The same dose of nicergoline induced similar effects on atropine-pretreated dogs. Guanethidine pretreatment (30 mg/kg i.v. the day before) prevented the hypotension but not the bradycardia induced by clonidine. Guanethidine prevented both the hypotension and the bradycardia induced by nicergoline. Thus, nicergoline, unlike clonidine, does not increase cardiac parasympathetic activity. When administered by the same route at the same doses, nicergoline did not change the slope and reduced the amplitude whereas clonidine increased both the slope and the amplitude of the heart period vs. blood pressure curve obtained by intravenous administration of phenylephrine. Taken together, these results suggest that nicergoline and clonidine probably act on different structures within the central nervous system.
在水合氯醛麻醉的犬中，脑池内给予尼麦角林（5微克/千克）或可乐定（4微克/千克）可导致血压和心率显著降低。相同剂量的尼麦角林对阿托品预处理的犬产生类似作用。胍乙啶预处理（前一天静脉注射30毫克/千克）可预防可乐定诱导的低血压，但不能预防心动过缓。胍乙啶可预防尼麦角林诱导的低血压和心动过缓。因此，与可乐定不同，尼麦角林不会增加心脏副交感神经活动。当以相同剂量通过相同途径给药时，尼麦角林不会改变斜率但会降低幅度，而可乐定则会增加通过静脉注射去氧肾上腺素获得的心动周期与血压曲线的斜率和幅度。综上所述，这些结果表明尼麦角林和可乐定可能作用于中枢神经系统内的不同结构。
