结缔组织对气管平滑肌收缩的抑制作用。

Attenuation of tracheal smooth muscle contraction by connective tissue.

作者信息

Mitchell H W, Yu L L

出版信息

Eur J Pharmacol. 1985 Nov 26;118(1-2):171-4. doi: 10.1016/0014-2999(85)90676-4.

Abstract

Removing the fibroelastic connective tissue, which surrounds the smooth muscle of the pig trachea, enhanced contractions and decreased desensitization in vitro in response to histamine. There were no differences between the preparations in the presence of indomethacin. The magnitude of contraction to acetylcholine was not significantly different. Incubation of the connective tissue in histamine solution caused the appearance of a substance(s) which relaxed other, precontracted tracheal muscles. Propranolol did not block this relaxation. Intact connective tissue appears to reduce the reactivity of the tracheal smooth muscle to histamine.

摘要

去除猪气管平滑肌周围的纤维弹性结缔组织，可增强体外对组胺的收缩反应并减少脱敏现象。在吲哚美辛存在的情况下，各制剂之间没有差异。对乙酰胆碱的收缩幅度没有显著差异。将结缔组织在组胺溶液中孵育会导致一种能使其他预先收缩的气管肌肉舒张的物质出现。普萘洛尔不能阻断这种舒张作用。完整的结缔组织似乎会降低气管平滑肌对组胺的反应性。