• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

与吲达帕胺相关的利尿药。II. 1-烷基、1-羧基烷基和1,3-二烷基取代的2-(4-氯-3-氨磺酰基苯甲酰胺基)异吲哚啉的合成及药理活性

Diuretic agents related to indapamide. II. Synthesis and pharmacological activity of 1-alkyl, 1-carboxyalkyl- and 1,3-dialkyl substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines.

作者信息

Sanna P, Cignarella G, Anania V, Siri R, Desole M S

出版信息

Farmaco Sci. 1985 Oct;40(10):777-85.

PMID:4085641
Abstract

In pursuing earlier studies, the synthesis of a series of 1 and 1,3- substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines (V a-e), related to indapamide, is described. These compounds were evaluated for diuretic and antihypertensive activities.

摘要

在早期研究中，描述了一系列与吲达帕胺相关的1-和1,3-取代的2-(4-氯-3-氨磺酰基苯甲酰胺基)异吲哚啉(V a - e)的合成。对这些化合物的利尿和抗高血压活性进行了评估。

相似文献

1
Diuretic agents related to indapamide. II. Synthesis and pharmacological activity of 1-alkyl, 1-carboxyalkyl- and 1,3-dialkyl substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines.与吲达帕胺相关的利尿药。II. 1-烷基、1-羧基烷基和1,3-二烷基取代的2-(4-氯-3-氨磺酰基苯甲酰胺基)异吲哚啉的合成及药理活性
Farmaco Sci. 1985 Oct;40(10):777-85.
2
Diuretic agents related to indapamide. III--Synthesis and pharmacological activity of N-(4-chloro-3-sulfamoylbenzamido)-1,2,3,4-tetrahydroquinolines and 1,2,3,4-tetrahydroisoquinolines.
Farmaco. 1989 Nov;44(11):1059-68.
3
Diuretic agents related to indapamide. IV--Synthesis and pharmacological activity of N-(4-chloro-3-sulfamoylbenzamido)-methyl-phenyl-pyrrolidines and N1-(4-chloro-3-sulfamoylbenzoyl)-N2-aryl- or aralkyl-alkyl-hydrazines.与吲达帕胺相关的利尿药。IV - N-(4-氯-3-氨磺酰基苯甲酰胺基)-甲基-苯基-吡咯烷和N1-(4-氯-3-氨磺酰基苯甲酰基)-N2-芳基-或芳烷基-烷基肼的合成及药理活性
Farmaco. 1991 Apr;46(4):527-38.
4
Diuretic agents related to indapamide. 1. Synthesis and activity of 1-substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines.与吲达帕胺相关的利尿药。1. 1-取代-2-(4-氯-3-氨磺酰基苯甲酰胺基)异吲哚啉的合成与活性
J Med Chem. 1981 Aug;24(8):1003-6. doi: 10.1021/jm00140a018.
5
[C-alkylpiperazines. XII. Synthesis and diuretic activity of compounds structurally related to clopamide].[C-烷基哌嗪。十二。与氯噻嗪结构相关的化合物的合成及利尿活性]
Farmaco Sci. 1987 Mar;42(3):191-204.
6
Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents.新型官能化3-取代[1,2,4]三唑并[4,3-a]嘧啶衍生物的合成：潜在的抗高血压药物。
Acta Pol Pharm. 2011 Mar-Apr;68(2):237-47.
7
Antihypertensive and antithrombotic activities of 6-(substituted phenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones.6-（取代苯基）-5-羟甲基-4,5-二氢-3（2H）哒嗪酮的抗高血压和抗血栓形成活性
Farmaco Sci. 1987 Aug;42(8):585-94.
8
[Synthesis and preliminary pharmacological screening of 2,4-disubstituted N,N-dialkyl-1,8-naphthyridine-3-carboxamides].[2,4-二取代的N,N-二烷基-1,8-萘啶-3-甲酰胺的合成及初步药理筛选]
Farmaco. 1989 Sep;44(9):865-81.
9
Diuretic and hypotensive activities of 4-anilino derivatives of 2-methylthiopyrido[2,3-d]pyrimidines.2-甲硫基吡啶并[2,3-d]嘧啶的4-苯胺基衍生物的利尿和降压活性
Arzneimittelforschung. 1990 Nov;40(11):1230-3.
10
Alteration of renal receptors for atrial natriuretic peptide and vasopressin in spontaneously hypertensive rats treated with antihypertensive diuretics.用抗高血压利尿剂治疗的自发性高血压大鼠心房利钠肽和血管加压素肾受体的改变
Res Commun Chem Pathol Pharmacol. 1994 Feb;83(2):165-78.

引用本文的文献

1
Targeted next generation sequencing of nine osteoporosis-related genes in the Wnt signaling pathway among Chinese postmenopausal women.中国绝经后女性中Wnt信号通路9个骨质疏松相关基因的靶向二代测序
Endocrine. 2020 Jun;68(3):669-678. doi: 10.1007/s12020-020-02248-x. Epub 2020 Mar 8.
2
Molecular modeling study of isoindolines as L-type Ca(2+) channel blockers by docking calculations.异吲哚啉类作为 L 型钙通道阻滞剂的分子建模研究：通过对接计算。
J Mol Model. 2010 Aug;16(8):1377-82. doi: 10.1007/s00894-010-0643-6. Epub 2010 Feb 12.