与吲达帕胺相关的利尿药。II. 1-烷基、1-羧基烷基和1,3-二烷基取代的2-(4-氯-3-氨磺酰基苯甲酰胺基)异吲哚啉的合成及药理活性
Diuretic agents related to indapamide. II. Synthesis and pharmacological activity of 1-alkyl, 1-carboxyalkyl- and 1,3-dialkyl substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines.
作者信息
Sanna P, Cignarella G, Anania V, Siri R, Desole M S
出版信息
Farmaco Sci. 1985 Oct;40(10):777-85.
PMID:4085641
Abstract
In pursuing earlier studies, the synthesis of a series of 1 and 1,3- substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines (V a-e), related to indapamide, is described. These compounds were evaluated for diuretic and antihypertensive activities.
摘要
在早期研究中，描述了一系列与吲达帕胺相关的1-和1,3-取代的2-(4-氯-3-氨磺酰基苯甲酰胺基)异吲哚啉(V a - e)的合成。对这些化合物的利尿和抗高血压活性进行了评估。
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