[吡啶并[3',2':4,5]噻吩并[3,2 - d]嘧啶 - 4(3H)-酮的3 - 取代衍生物的合成及镇痛活性]
[Synthesis and analgesic activity of 3-substituted derivatives of pyrido [3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-ones].
作者信息
Bousquet E, Romeo G, Guerrera F, Caruso A, Amico-Roxas M
出版信息
Farmaco Sci. 1985 Nov;40(11):869-74.
PMID:4085646
Abstract
A series of Schiff bases of 3-amino-2,7,9-trimethylpyrido-[3',2',:4,5]thieno[3,2-d]pyrimidin- 4(3H)-one with aromatic aldehydes was synthesized. The compounds showed interesting analgesic activity without effects on the stomach even with oral doses of 200 mg/kg.
摘要
合成了一系列3-氨基-2,7,9-三甲基吡啶并[3',2',:4,5]噻吩并[3,2-d]嘧啶-4(3H)-酮与芳香醛的席夫碱。这些化合物显示出有趣的镇痛活性，即使口服剂量为200mg/kg也对胃无影响。
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