Alshareef Muneera, Bokhari Samia A, Nawaz Arsalan, Arfaj Lama, Alsharif Al Hussein, Alshamrani Haidar, Al-Bogami Fahad, Altowairqi Maram, Aqabaw Sally, Alobisi Abdullah, Al-Ard Yasir, Alsharifb Homam Talal
From the Department of Endocrinology and Diabetes, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabi.
From the Department of Internal Medicine, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
Ann Saudi Med. 2025 Aug 28:1-8. doi: 10.5144/0256-4947.2025.28.08.1200.
Diabetic ketoacidosis (DKA) is a potentially fatal complication of type 1 diabetes mellitus (T1DM). To our knowledge, limited studies have examined the risk factors of recurrent DKA in the Saudi T1DM population.
To identify factors contributing to recurrent DKA in Saudi patients with T1DM. By identifying the contributing factors for DKA recurrence the disease burden can be mitigated by making targeted interventions.
Retrospective.
Tertiary care center, Jeddah, Saudi Arabia.
Saudi patients with T1DM admitted with DKA between 2021 to 2023 were included. A comparative analysis was performed between patients with a single recurrence of DKA and those with multiple recurrent admissions.
Association between multiple variables and recurrent DKA.
245 Saudi patients with T1DM.
A total of 245 Saudi patients with T1DM were included. A significantly higher proportion of females were observed in the multiple recurrent DKA group (73.1% vs. 48.5%, =.0001). Also, a higher proportion of single individuals were found among the multiple recurrent DKA group (=.006). Longer duration of T1DM (≥5 years) and presence of microalbuminuria were more associated with multiple recurrent DKA than single recurrence of DKA. Among the precipitating factors, non-adherence to medications was associated with multiple recurrence of DKA (=.02).
This study has identified several risk factors contributing to recurrent DKA episodes among Saudi patients with T1DM. By increasing awareness of these factors among both healthcare providers and the community, we can develop more effective prevention strategies and ultimately reduce the incidence of recurrent DKA.
A retrospective study and single-center experience.
糖尿病酮症酸中毒（DKA）是1型糖尿病（T1DM）的一种潜在致命并发症。据我们所知，针对沙特T1DM人群中复发性DKA的危险因素的研究有限。
确定沙特T1DM患者复发性DKA的影响因素。通过确定DKA复发的影响因素，可通过有针对性的干预减轻疾病负担。
回顾性研究。
沙特阿拉伯吉达的三级医疗中心。
纳入2021年至2023年间因DKA入院的沙特T1DM患者。对单次复发DKA的患者和多次复发入院的患者进行了比较分析。
多个变量与复发性DKA之间的关联。
245例沙特T1DM患者。
共纳入245例沙特T1DM患者。多次复发性DKA组中女性比例显著更高（73.1%对48.5%，P = 0.0001）。此外，多次复发性DKA组中单身个体的比例更高（P = 0.006）。T1DM病程较长（≥5年）和存在微量白蛋白尿与多次复发性DKA的关联比单次复发DKA更强。在诱发因素中，不遵医嘱用药与DKA的多次复发相关（P = 0.02）。
本研究确定了沙特T1DM患者复发性DKA发作的几个危险因素。通过提高医疗服务提供者和社区对这些因素的认识，我们可以制定更有效的预防策略，并最终降低复发性DKA的发生率。
回顾性研究和单中心经验。
