Expression of Concern: The IkappaB Kinase Family Phosphorylates the Parkinson's Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling.
出版信息
PLoS One. 2025 Aug 26;20(8):e0330958. doi: 10.1371/journal.pone.0330958. eCollection 2025.
Abstract
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1
Expression of Concern: The IkappaB Kinase Family Phosphorylates the Parkinson's Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling.关注声明：在Toll样受体信号传导过程中，IkappaB激酶家族在Ser935和Ser910位点使帕金森病相关激酶LRRK2发生磷酸化。
PLoS One. 2025 Aug 26;20(8):e0330958. doi: 10.1371/journal.pone.0330958. eCollection 2025.
2
The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling.IκB 激酶家族在 Toll 样受体信号转导过程中使帕金森病激酶 LRRK2 磷酸化 Ser935 和 Ser910。
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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.LRRK2 激酶活性的抑制导致 Ser(910)/Ser(935)去磷酸化，破坏 14-3-3 结合并改变细胞质定位。
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Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition.LRRK2 丝氨酸 955 和 973 的磷酸化被帕金森病突变和 LRRK2 药理学抑制所破坏。
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Lack of correlation between the kinase activity of LRRK2 harboring kinase-modifying mutations and its phosphorylation at Ser910, 935, and Ser955.携带激酶修饰突变的LRRK2激酶活性与其在Ser910、935和Ser955位点的磷酸化之间缺乏相关性。
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本文引用的文献
1
The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling.IκB 激酶家族在 Toll 样受体信号转导过程中使帕金森病激酶 LRRK2 磷酸化 Ser935 和 Ser910。
PLoS One. 2012;7(6):e39132. doi: 10.1371/journal.pone.0039132. Epub 2012 Jun 18.
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