Hasstedt S J, Kuida H, Ash K O, Williams R R
Genet Epidemiol. 1985;2(4):339-48. doi: 10.1002/gepi.1370020403.
Household effects accounted for significant proportions of the observed variance of high density lipoprotein cholesterol (HDL-C) and subfractions HDL2 and HDL3. It was found that 19.3% of HDL-C variance could be attributed to a juvenile sib effect (under age 18); 17.4% of HDL2 variance could be attributed to a sib effect (of any age); and 22.1% and 32.6% of the HDL3 variance could be attributed to a parent-offspring effect and a sib effect (of any age), respectively. In addition, additive genetic effects accounted for 56.5%, 37.3%, and 28.3% of the variances of HDL-C, HDL2, and HDL3, respectively. These are maximum likelihood estimates obtained using a variance components model on 2,149 HDL-C levels measured on members of 54 Utah pedigrees, and 337 HDL2 and HDL3 levels measured on a subset of 14 pedigrees.
家庭效应在高密度脂蛋白胆固醇（HDL-C）及其亚组分HDL2和HDL3的观察变异中占很大比例。研究发现，19.3%的HDL-C变异可归因于青少年同胞效应（18岁以下）；17.4%的HDL2变异可归因于同胞效应（任何年龄）；HDL3变异的22.1%和32.6%可分别归因于亲子效应和同胞效应（任何年龄）。此外，加性遗传效应分别占HDL-C、HDL2和HDL3变异的56.5%、37.3%和28.3%。这些是使用方差成分模型对54个犹他州家系成员测量的2149个HDL-C水平以及14个家系子集测量的337个HDL2和HDL3水平获得的最大似然估计值。
