3723例原发性口腔鳞状细胞癌患者的人口统计学和临床病理特征：一项为期11年（2012 - 2023年）的单中心连续研究
Demographic and Clinicopathologic Characteristics of 3723 Patients with Primary Oral Squamous Cell Carcinoma: A Consecutive, Single-Center Study Over 11 Years (2012-2023).
作者信息
Xiao Yao, Cao Lei-Ming, Zhu Zhao-Qi, Wang Xiao-Hu, Wang Guang-Rui, Zhou Kan, Yu Yi-Fu, Zhang Yi-Jia-Ning, Shen Ke-Ru, Liu Jing-Yi, Li Zi-Zhan, Liu Xuan-Hao, Luo Han-Yue, Zhang Si-Jie, Wang Kang-Ning, Mak Chon-Hou, Wei Li-Ya, Ma Zhi-Gong, Liang Run-Feng, Wei Hao, Xu Zhen-Yu, Wang Wei-Yu, Qiu Yu-Zhong, Tang Yun, Xiong Xue-Peng, Jia Jun, Bu Lin-Lin, Liu Bing
机构信息
State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Department of Oral and Maxillofacial - Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
出版信息
Ann Surg Oncol. 2025 Aug 26. doi: 10.1245/s10434-025-18044-8.
OBJECTIVE
This study aimed to investigate the demographic and clinicopathologic characteristics of oral squamous cell carcinoma (OSCC) and explore the risk factors associated with OSCC pathological TNM (pTNM) stage.
METHODS
This retrospective study included patients with OSCC from 2012 to 2023. Data analyzed included demographics, clinicopathological characteristics, and treatment. Age differences were analyzed using the Mann-Whitney U test. Categorical variables were presented as percentages and were compared using the Chi-square or Fisher's exact tests. Logistic regression was used for multivariate analysis.
RESULTS
A total of 3723 patients were analyzed and the male:female ratio was 2.35:1. Patients aged 45-59 years accounted for the largest proportion (37%, 1377/3723) of patients, and 90.7% (3375/3723) were from Hubei Province of China. The most commonly affected site was the body of the tongue (45.8%, 1704/3723). Moderately differentiated OSCC patients accounted for 54.9% (2045/3723) of the study cohort. The percentage of patients with locally advanced-stage OSCC (pTNM stage III/IV) was 41.2% (1534/3723). Patients of different sexes with OSCC at different sites were statistically different in respect to clinicopathological characteristics. 3057 patients underwent neck dissection, while 39.3% (1201/3057) had positive lymph nodes. Alcohol consumption, age >50 years, and perineural invasion (PNI) were independent risk factors for locally advanced OSCC (p < 0.05).
CONCLUSIONS
OSCC is more common in males and the most common site was the body of the tongue. Alcohol consumption, age > 50 years, and PNI were independent risk factors for locally advanced OSCC. The limitations include selection bias from a single-center study and the lack of prognostic data. Future studies should explore OSCC heterogeneity and enhance preventive strategies for patients who had risk factors.
目的
本研究旨在调查口腔鳞状细胞癌（OSCC）的人口统计学和临床病理特征，并探索与OSCC病理TNM（pTNM）分期相关的危险因素。
方法
本回顾性研究纳入了2012年至2023年的OSCC患者。分析的数据包括人口统计学、临床病理特征和治疗情况。采用Mann-Whitney U检验分析年龄差异。分类变量以百分比表示，并使用卡方检验或Fisher精确检验进行比较。采用逻辑回归进行多变量分析。
结果
共分析了3723例患者，男女比例为2.35:1。45-59岁的患者占比最大（37%，1377/3723），90.7%（3375/3723）来自中国湖北省。最常受累部位是舌体（45.8%，1704/3723）。中度分化的OSCC患者占研究队列的54.9%（2045/3723）。局部晚期OSCC（pTNM III/IV期）患者的比例为41.2%（1534/3723）。不同性别、不同部位的OSCC患者在临床病理特征方面存在统计学差异。3057例患者接受了颈部清扫术，其中39.3%（1201/3057）有阳性淋巴结。饮酒、年龄>50岁和神经周围侵犯（PNI）是局部晚期OSCC的独立危险因素（p<0.05）。
结论
OSCC在男性中更为常见，最常见的部位是舌体。饮酒、年龄>50岁和PNI是局部晚期OSCC的独立危险因素。局限性包括单中心研究的选择偏倚以及缺乏预后数据。未来的研究应探索OSCC的异质性，并加强对有危险因素患者的预防策略。
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