Chatamra K, Daniel P M, Kendall M D, Lam D K
Horm Metab Res. 1985 Dec;17(12):630-2. doi: 10.1055/s-2007-1013630.
The thymus atrophied rapidly in rats rendered diabetic by a single injection of streptozotocin. The weight of the gland was reduced to one-fifth of its original weight within three weeks. Histologically there was a great loss of cortical thymocytes and a marked increase in mast cells lying in the thickened fibrous tissue. These findings may have a bearing on the state of immune deficiency observed in animals with diabetes induced by streptozotocin.
单次注射链脲佐菌素使大鼠患糖尿病后，胸腺迅速萎缩。三周内，胸腺重量降至原来的五分之一。组织学检查发现，皮质胸腺细胞大量丢失，增厚的纤维组织中的肥大细胞显著增多。这些发现可能与链脲佐菌素诱导的糖尿病动物中观察到的免疫缺陷状态有关。
