Mo Liqun, Zeng Xu, Liu Yu, Zhang Jin, Liu Li, Zhang Yingying, Bai Yiping
Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, Sichuan, 646000, People's Republic of China.
Drug Des Devel Ther. 2025 Aug 20;19:7185-7205. doi: 10.2147/DDDT.S532658. eCollection 2025.
Irisin, a myokine secreted by skeletal muscle, has garnered significant attention for its multifaceted physiological roles and emerging potential as both a biomarker and therapeutic target in oncology. This review consolidates current understanding of irisin's impact across various malignancies, focusing on its complex regulation of tumorigenesis through interactions with key signaling pathways including PI3K/AKT, AMPK-mTOR, and STAT3/Snail. Critically, irisin exhibits a paradoxical dual role: it suppresses proliferation, migration, and invasion in cancers such as lung, breast, and pancreatic carcinoma, yet paradoxically promotes the progression of hepatocellular carcinoma. This tissue-specific dichotomy presents a significant therapeutic challenge. Furthermore, inconsistent findings regarding irisin expression levels even within the same tumor type highlight the urgent need for further mechanistic investigation. Future research must prioritize elucidating the context-dependent mechanisms of irisin within the tumor microenvironment and rigorously evaluating its clinical utility as a biomarker through large-scale trials. Resolving these contradictions is essential for developing a unified understanding of irisin's role in cancer biology. Such insights hold promise for paving the way toward novel therapeutic strategies, potentially enhancing the efficacy of personalized cancer therapy.
鸢尾素是一种由骨骼肌分泌的肌动蛋白，因其多方面的生理作用以及作为肿瘤学中生物标志物和治疗靶点的潜在价值而备受关注。本综述总结了目前对鸢尾素在各种恶性肿瘤中影响的认识，重点关注其通过与包括PI3K/AKT、AMPK-mTOR和STAT3/Snail在内的关键信号通路相互作用对肿瘤发生的复杂调控。至关重要的是，鸢尾素表现出一种矛盾的双重作用：它抑制肺癌、乳腺癌和胰腺癌等癌症的增殖、迁移和侵袭，但矛盾的是，它却促进肝细胞癌的进展。这种组织特异性的二分法带来了重大的治疗挑战。此外，即使在同一肿瘤类型中，关于鸢尾素表达水平的研究结果也不一致，这凸显了进一步进行机制研究的迫切需求。未来的研究必须优先阐明鸢尾素在肿瘤微环境中的背景依赖性机制，并通过大规模试验严格评估其作为生物标志物的临床效用。解决这些矛盾对于形成对鸢尾素在癌症生物学中作用的统一理解至关重要。这些见解有望为新的治疗策略铺平道路，潜在地提高个性化癌症治疗的疗效。
