Galgóczy László
Department of Biotechnology and Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged 6726, Hungary.
ACS Bio Med Chem Au. 2025 Jul 2;5(4):531-552. doi: 10.1021/acsbiomedchemau.5c00103. eCollection 2025 Aug 20.
The prevalence of fungal infections and contamination has increased alarmingly over the past decade, posing a significant threat to human health and the food supply and negatively affecting welfare. This escalating concern is primarily attributed to the lack of safe, effective, and widely available antifungal agents; the increasing spread of (multi)-drug resistance to conventional antifungal treatments; and substantial epidemiological shifts in fungal pathogens. Decision-making bodies have recognized the urgency of this situation and prioritized efforts to address and mitigate the spread of drug-resistant fungal infections by developing and implementing innovative antifungal strategies, including using drug combinations, designing fundamentally new antifungal compounds with fungus-specific mechanisms of action and a minimal risk of resistance development, drug repurposing, and exploring alternative approaches, such as biomolecules, nanotechnology, and biological control. This review aims to provide a comprehensive overview of the current challenges associated with fungal infections in medicine and agriculture as well as the latest advancements and potential solutions.
在过去十年中，真菌感染和污染的发生率急剧上升，对人类健康和粮食供应构成重大威胁，并对福利产生负面影响。这种日益加剧的担忧主要归因于缺乏安全、有效且广泛可用的抗真菌药物；对传统抗真菌治疗的（多重）耐药性不断蔓延；以及真菌病原体在流行病学上的重大转变。决策机构已经认识到这种情况的紧迫性，并将通过制定和实施创新的抗真菌策略来应对和减轻耐药真菌感染的传播作为优先事项，这些策略包括使用联合用药、设计具有真菌特异性作用机制且产生耐药性风险极小的全新抗真菌化合物、药物重新利用以及探索替代方法，如生物分子、纳米技术和生物防治。本综述旨在全面概述医学和农业中与真菌感染相关的当前挑战以及最新进展和潜在解决方案。
