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比较经颅随机噪声刺激和经颅直流电刺激对男性与女性运动皮层运动表现的影响:一项随机对照交叉研究。

Comparing the effect of transcranial random noise stimulation and transcranial direct current stimulation over the motor cortex on motor performance in men vs. women: a randomized controlled crossover study.

作者信息

Frankel Elchanan, Friedman Jason, Frenkel-Toledo Silvi

机构信息

Department of Physical Therapy, School of Health Sciences, Ariel University, Ariel, Israel.

Department of Physical Therapy, Stanley Steyer School of Health Professions, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

出版信息

Front Hum Neurosci. 2025 Aug 8;19:1577899. doi: 10.3389/fnhum.2025.1577899. eCollection 2025.

Abstract

Non-invasive Brain Stimulation may modulate motor function. One commonly investigated method is transcranial direct current stimulation (tDCS). In the last few years, a new stimulation technique has been developed and studied, namely transcranial random noise stimulation (tRNS). Both stimulation techniques have displayed a certain degree of inconsistency regarding their impact on motor performance. One explanation for this may be related to differences in the sex of the participants. Thirty healthy individuals (15 female) participated in a single-blind counterbalanced crossover trial. All participants received three stimulation conditions: high frequency-tRNS, tDCS, and sham stimulation. Stimulation was applied for 10 min at 1.0 mA, with a frequency range of 101-640 Hz for the tRNS. In all stimulation conditions, the anode (for tDCS) was placed over C4 and the cathode over the contralateral orbit. The participants performed a sequential reaching motor task on a digital tablet before, during, and immediately after the stimulation. Movement time, reaction time, and peak velocity did not differ between stimulation conditions. However, within-condition analyses showed improvements in movement time and peak velocity following tRNS only, while reaction time improved in all stimulation conditions. No significant effect of sex was observed. While no clear advantage for a specific stimulation condition was statistically confirmed, these within-condition effects suggest that tRNS may modestly enhance motor performance and warrant further investigation. Additionally, in this experimental setup, sex did not influence the effects of tRNS and tDCS on motor performance.

摘要

非侵入性脑刺激可能会调节运动功能。一种常用的研究方法是经颅直流电刺激(tDCS)。在过去几年中,一种新的刺激技术已被开发和研究,即经颅随机噪声刺激(tRNS)。这两种刺激技术在对运动表现的影响方面都表现出一定程度的不一致性。对此的一种解释可能与参与者的性别差异有关。30名健康个体(15名女性)参与了一项单盲平衡交叉试验。所有参与者都接受了三种刺激条件:高频tRNS、tDCS和假刺激。以1.0 mA的电流施加刺激10分钟,tRNS的频率范围为101 - 640 Hz。在所有刺激条件下,阳极(用于tDCS)置于C4上方,阴极置于对侧眼眶上方。参与者在刺激前、刺激期间和刺激后立即在数字平板电脑上执行连续伸手运动任务。刺激条件之间的运动时间、反应时间和峰值速度没有差异。然而,条件内分析显示,仅tRNS后运动时间和峰值速度有所改善,而所有刺激条件下反应时间均有所改善。未观察到性别有显著影响。虽然在统计学上未证实特定刺激条件有明显优势,但这些条件内效应表明tRNS可能适度提高运动表现,值得进一步研究。此外,在这个实验设置中,性别并未影响tRNS和tDCS对运动表现的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6aa/12371575/c1d927b6529f/fnhum-19-1577899-g001.jpg

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