Diehl L W
MMW Munch Med Wochenschr. 1977 Jun 24;119(25):857-60.
As more recent investigations have shown, many women regularly take drugs not prescribed by the doctor during pregnancy, in addition to those that are. It is not always a matter of diseases which require treatment. It is shown, with reference to a number of patients, that unproblematic longterm anticonvulsant therapy - with years practically free from attack - can be complicated by pregnancy. During an essential treatment with multiple drugs made necessary by the pregnancy, 6 attacks of grand mal were recorded in 6 months and sometimes very low serum DPH concentrations were found in spite of reliable, high doses of Zentropil.
正如最近的调查所示,许多女性在孕期除了服用医生开的药之外,还经常服用非医嘱药物。这并不总是因为需要治疗的疾病。有针对一些患者的研究表明,原本没问题的长期抗惊厥治疗(多年来几乎没有发作)在孕期可能会变得复杂。在因怀孕而必须进行的多种药物联合治疗期间,6个月内记录到6次癫痫大发作,尽管可靠地服用了高剂量的Zentropil,但有时仍发现血清苯妥英浓度非常低。