Abiodun Olugbenga O, Salau Ibrahim L, Anya Tina
Department of Internal Medicine, Federal Medical Centre, Abuja, Nigeria.
Department of Internal Medicine, Baze University Abuja, Nigeria.
Glob Heart. 2025 Aug 19;20(1):67. doi: 10.5334/gh.1455. eCollection 2025.
The burden of degenerative valve disease is increasing globally because of population aging. However, data on this condition is scarce in Nigeria and across Africa.
Our study evaluated the prevalence, pattern, and associations of aortic sclerosis and degenerative valve disease in a Nigerian population.
Data of a total of 4030 patients were analyzed retrospectively from the Federal Medical Centre Abuja transthoracic echocardiographic registry from January 2020 to December 2024. Patients were 18 years and above. Aortic sclerosis, degenerative mitral valve disease, calcific aortic valve disease, and degenerative valve disease were defined in accordance with the report of the American Heart Association/American College of Cardiology guidelines.
The mean age of patients was 52 ± 15 years and 53.2% were female. The prevalence rates were 4.2% for aortic sclerosis, 0.2% for degenerative mitral valve disease, 1.2% for calcific aortic valve disease, and 1.3% for degenerative valve disease. Among patients aged 65 years and older, the prevalences rates were higher for aortic sclerosis (13.2%), degenerative mitral valve disease (1.0%), calcific aortic valve disease (3.4%), and degenerative valve disease (3.9%) [ < 0.001]. Only 1.7% and 0.6% of those <65 years had aortic sclerosis and calcific aortic valve disease, respectively. Patients aged 65 years and older, and hypertension had odds ratio (OR) of 7.99 and 3.98 for developing aortic sclerosis, respectively. For calcific aortic valve disease, the OR was higher for patients aged 65 years and older (OR: 4.25), hypertension (OR: 2.48), and left ventricular hypertrophy (OR: 5.35) [ < 0.001].
In this Nigerian echocardiographic registry, age above 65 years and hypertension were associated with aortic sclerosis and calcific aortic valve disease.
由于人口老龄化，退行性瓣膜病在全球的负担正在增加。然而，在尼日利亚及整个非洲，关于这种疾病的数据很少。
我们的研究评估了尼日利亚人群中主动脉硬化和退行性瓣膜病的患病率、模式及相关性。
回顾性分析了2020年1月至2024年12月期间联邦医疗中心阿布贾经胸超声心动图登记处的4030例患者的数据。患者年龄在18岁及以上。主动脉硬化、退行性二尖瓣疾病、钙化性主动脉瓣疾病和退行性瓣膜病根据美国心脏协会/美国心脏病学会指南的报告进行定义。
患者的平均年龄为52±15岁，女性占53.2%。主动脉硬化的患病率为4.2%，退行性二尖瓣疾病为0.2%，钙化性主动脉瓣疾病为1.2%，退行性瓣膜病为1.3%。在65岁及以上的患者中，主动脉硬化（13.2%）、退行性二尖瓣疾病（1.0%）、钙化性主动脉瓣疾病（3.4%）和退行性瓣膜病（3.9%）的患病率更高[P<0.001]。65岁以下的患者中，分别只有1.7%和0.6%患有主动脉硬化和钙化性主动脉瓣疾病。65岁及以上的患者和高血压患者发生主动脉硬化的比值比（OR）分别为7.99和3.98。对于钙化性主动脉瓣疾病，65岁及以上的患者（OR：4.25）、高血压患者（OR：2.48）和左心室肥厚患者（OR：5.35）的OR更高[P<0.001]。
在这个尼日利亚超声心动图登记处中，65岁以上年龄和高血压与主动脉硬化和钙化性主动脉瓣疾病相关。
