Wang Xin, Cui Pingping, Deng Yongqi, Zhang Baohua, Gao Zhihui, Li Tangyue, Yin Yingchun, Li Jing
School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China.
Department of Pathology, Zibo Central Hospital, Zibo, Shandong 255020, P.R. China.
Oncol Lett. 2025 Aug 14;30(4):483. doi: 10.3892/ol.2025.15230. eCollection 2025 Oct.
Immune escape is a phenomenon in which tumor cells or infections evade detection and clearance by the host immune system in various ways. During an antitumor immune response, cells increase the concentration of pentameric stalk, which enhances antigen presentation and recognition by the immune system. It has been found that both increased and decreased levels of specificity protein 1 () control oncogenes, thereby influencing tumorigenesis and cancer development. Thus, elucidating the mechanism underlying the role of in tumors may help identify novel prognostic indicators. However, the immune escape mechanism involved in poses new challenges to diagnosis and treatment. The present review used a combination of analogies and summaries to explore the structure, function, regulatory mechanism and biological activity of in normal and cancer cells, and aimed to discuss the regulatory function of in different tumors, as well as the relevant association between and clinical diagnosis and treatment, which revealed the importance of in tumorigenesis and cancer development. The novelty of the present review lies in the identification of novel immune evasion mechanisms and immunotherapeutic techniques that provide new insights and approaches for a deeper understanding of the role of in malignant tumors.
免疫逃逸是肿瘤细胞或感染以多种方式逃避宿主免疫系统检测和清除的一种现象。在抗肿瘤免疫反应过程中，细胞会增加五聚体柄的浓度，这会增强免疫系统对抗原的呈递和识别。研究发现，特异性蛋白1（）水平的升高和降低均会调控癌基因，从而影响肿瘤发生和癌症发展。因此，阐明其在肿瘤中作用的潜在机制可能有助于识别新的预后指标。然而，其涉及的免疫逃逸机制给诊断和治疗带来了新挑战。本综述采用类比和总结相结合的方法，探讨其在正常细胞和癌细胞中的结构、功能、调控机制及生物学活性，旨在讨论其在不同肿瘤中的调控作用，以及其与临床诊断和治疗的相关联系，揭示了其在肿瘤发生和癌症发展中的重要性。本综述的新颖之处在于识别出了新的免疫逃逸机制和免疫治疗技术，为更深入理解其在恶性肿瘤中的作用提供了新的见解和方法。
