Li Cuili, Zhong Xi, Guo Shuxian, Liu Feifei, Song Yanhui, Zhao Zhiying, Jiang Guan
Department of Infectious Diseases, KingMed Diagnostics, Guangzhou, Guangdong, China.
Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Front Med (Lausanne). 2025 Aug 11;12:1644400. doi: 10.3389/fmed.2025.1644400. eCollection 2025.
() is a significant pathogenic fungus responsible for, causing sporotrichosis. Metagenomics capture (MetaCAP), a high-throughput sequencing technology for pathogen nucleic acid detection based on probe capture, facilitates early diagnosis of infections. Herein, we present a case of infection diagnosed using MetaCAP.
A 47 year-old female, initially diagnosed with reactive perforating collagenosis, developed epidermal erosion at the affected site after self-applying a poorly air-permeable topical patch purchased online. She subsequently exhibited progressive redness, edema, severe pruritus, and an increase in papules that coalesced into plaques following exposure to decaying wood. She revisited our hospital for further consultation. The diagnosis of sporotrichosis caused by was confirmed through a pathological examination of the affected skin tissue and MetaCAP testing. Then, she was treated with itraconazole and naftifine hydrochloride and ketoconazole cream. After a three-month follow-up, the patient's skin rash showed significant improvement.
A case of infection was promptly diagnosed through MetaCAP and effectively treated with itraconazole.
（）是一种重要的致病真菌，可导致孢子丝菌病。宏基因组捕获技术（MetaCAP）是一种基于探针捕获的用于病原体核酸检测的高通量测序技术，有助于孢子丝菌感染的早期诊断。在此，我们报告一例使用MetaCAP诊断的孢子丝菌感染病例。
一名47岁女性，最初被诊断为反应性穿通性胶原病，在自行涂抹从网上购买的透气性差的外用贴片后，患部出现表皮糜烂。随后，在接触腐烂木材后，她出现了进行性发红、水肿、严重瘙痒，丘疹增多并融合成斑块。她再次到我院进一步咨询。通过对患部皮肤组织进行病理检查和MetaCAP检测，确诊为由（）引起的孢子丝菌病。然后，她接受了伊曲康唑以及盐酸萘替芬酮康唑乳膏治疗。经过三个月的随访，患者皮疹有明显改善。
通过MetaCAP迅速诊断出一例孢子丝菌感染病例，并使用伊曲康唑进行了有效治疗。
